| Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction. | |
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MedLine Citation:
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PMID: 20640501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare embryo survival, pregnancy and implantation rates after cryopreservation of human cleavage-stage embryos with slow-rate cryopreservation or vitrification. STUDY DESIGN: 262 patients, attending for assisted reproduction, were prepared for oocyte retrieval using standard controlled ovarian hyperstimulation protocols. Excess embryos were cryopreserved on day 3 either by vitrification, or slow-rate cryopreservation in a programmable freezer. Cycles of thawing were monitored for thaw efficiency, pregnancy and implantation rates. RESULTS: Clinical pregnancy and implantation rates were highly comparable between cycles in which day 3 embryos were thawed either after slow-rate cryopreservation or vitrification. CONCLUSIONS: These data suggest that vitrification of human embryos during assisted reproduction cycles achieves comparable success rates to fresh cycles and therefore can be applied in the laboratory of assisted reproduction. |
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Authors:
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Martin Graham Wilding; Clemente Capobianco; Nadia Montanaro; Genc Kabili; Loredana Di Matteo; Enrico Fusco; Brian Dale |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-07-17 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 27 ISSN: 1573-7330 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-02-04 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: Netherlands |
Other Details:
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Languages: eng Pagination: 549-54 Citation Subset: IM |
Affiliation:
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Centro Fecondazione Assistita, Clinica Villa del Sole, Napoli, Italy. martinwilding@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cleavage Stage, Ovum* Cryopreservation / methods* Embryo Implantation* Embryo Transfer Female Humans Pregnancy Pregnancy Outcome Pregnancy Rate Prospective Studies Reproductive Techniques, Assisted Vitrification* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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