Document Detail

Human cleavage-stage embryo vitrification is comparable to slow-rate cryopreservation in cycles of assisted reproduction.
MedLine Citation:
PMID:  20640501     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare embryo survival, pregnancy and implantation rates after cryopreservation of human cleavage-stage embryos with slow-rate cryopreservation or vitrification.
STUDY DESIGN: 262 patients, attending for assisted reproduction, were prepared for oocyte retrieval using standard controlled ovarian hyperstimulation protocols. Excess embryos were cryopreserved on day 3 either by vitrification, or slow-rate cryopreservation in a programmable freezer. Cycles of thawing were monitored for thaw efficiency, pregnancy and implantation rates.
RESULTS: Clinical pregnancy and implantation rates were highly comparable between cycles in which day 3 embryos were thawed either after slow-rate cryopreservation or vitrification.
CONCLUSIONS: These data suggest that vitrification of human embryos during assisted reproduction cycles achieves comparable success rates to fresh cycles and therefore can be applied in the laboratory of assisted reproduction.
Martin Graham Wilding; Clemente Capobianco; Nadia Montanaro; Genc Kabili; Loredana Di Matteo; Enrico Fusco; Brian Dale
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-07-17
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  27     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-28     Completed Date:  2011-02-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  549-54     Citation Subset:  IM    
Centro Fecondazione Assistita, Clinica Villa del Sole, Napoli, Italy.
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MeSH Terms
Cleavage Stage, Ovum*
Cryopreservation / methods*
Embryo Implantation*
Embryo Transfer
Pregnancy Outcome
Pregnancy Rate
Prospective Studies
Reproductive Techniques, Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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