Document Detail


Human chorionic somatomammotropin, estriol and oxytocinase as indexes of fetal growth.
MedLine Citation:
PMID:  501507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A group of 56 women with high risk pregnancies were studied since the 32nd week of gestation. With the aim of obtaining reliable fetal growth indicators, maternal serum hCS, estriol and oxytocinase levels were determined. hCS and estriol were determined by specific radioimmunoassays and oxytocinase with a colorimetric method. Mean values obtained the week before delivery of both hormones and the enzyme were correlated with the weight of the newborns. The correlation coefficients were 0.30, 0.33 and 0.30 for hCS, estriol and oxytocinase respectively (Figs. 2, 3 and 4). The newborns were classified into two groups, small for date and adequate weight for gestational age. Maternal hCS level corresponding to newborns with adequate birthweight for their gestational age was 7.94 ug/ml. This value was statistically higher than that corresponding to the group of small-for-date newborns, which was 5.15 ug/ml (Fig. 5). Similar results were obtained when the maternal estriol levels were considered according to the birthweight (Fig. 7). The same analysis applied to oxytocinase values did not show statistically significant differences. Arbitrary critical levels were established for hCS and estriol at 7 ug/ml and 35 ng/ml respectively. When values were below these levels, newborns would have greater possibility of being small for dates (Figs. 6 and 8). The predictive value was best when both hormones were considered concomitantly (77%) (Fig. 9). These results indicate the suitability of considering hCS and estriol levels in order to assess fetal growth.
Authors:
G Giussi; J Vinacur; G Ballejo; E G Garófalo; I Martino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  7     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1979  
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  235-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminopeptidases / blood*
Birth Weight
Cystinyl Aminopeptidase / blood*,  physiology
Estriol / blood*,  physiology
Female
Fetus / physiology*
Growth Hormone / blood*,  physiology
Humans
Infant, Low Birth Weight
Infant, Newborn
Pregnancy
Pregnancy Complications / blood*
Chemical
Reg. No./Substance:
50-27-1/Estriol; 9002-72-6/Growth Hormone; EC 3.4.11.-/Aminopeptidases; EC 3.4.11.3/Cystinyl Aminopeptidase

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