Document Detail


Human chorionic gonadotropin supplementation in recurring pregnancy loss: a controlled trial.
MedLine Citation:
PMID:  7646609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the efficacy of hCG in the management of recurrent early pregnancy loss. DESIGN: A prospective, randomized, controlled trial. SETTING: Miscarriage Clinic, Women's Hospital, Liverpool, United Kingdom. SUBJECTS: Eighty-one women attending the miscarriage clinic with idiopathic recurrent pregnancy loss were randomized to receive hCG supplementation or placebo in early pregnancy. MAIN OUTCOME MEASURE: The success rate or live birth rate. RESULTS: In women with regular menstrual cycles it was found that hCG had no beneficial effect, the pregnancy success rate being 86% in both groups. However, women with oligomenorrhea had a pregnancy success rate of 40% in the placebo group but a statistically significant improvement to 86% if hCG was given. CONCLUSIONS: Human chorionic gonadotropin can be recommended for idiopathic recurrent pregnancy loss in women with oligomenorrhea.
Authors:
S Quenby; R G Farquharson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  62     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-01     Completed Date:  1994-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  708-10     Citation Subset:  IM    
Affiliation:
Miscarriage Clinic, Women's Hospital, Liverpool, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / complications,  drug therapy*
Adult
Chorionic Gonadotropin / therapeutic use*
Female
Humans
Menstrual Cycle
Oligomenorrhea / complications
Pregnancy
Pregnancy Outcome
Prospective Studies
Reference Values
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin
Comments/Corrections
Comment In:
Fertil Steril. 1995 Jul;64(1):215-6; author reply 216-7   [PMID:  7789567 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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