Document Detail

Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy.
MedLine Citation:
PMID:  19046581     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To analyze the value of the hCG ratio of peritoneal serum versus venous serum (R(P/V)) for early diagnosis and prognostic evaluation of ectopic pregnancy (EP). DESIGN: Retrospective clinical study. SETTING: University hospital. PATIENT(S): One hundred three women with hemoperitoneum and positive urine hCG tests underwent laparoscopy or laparotomy. INTERVENTION(S): Venous serum and peritoneal serum samples were obtained; ultrasound was performed in all the patients; dilatation and curettage was used in 28 patients. MAIN OUTCOME MEASURE(S): Quantitative hCG and R(P/V). RESULT(S): The R(P/V) in EP (5.55 +/- 4.32) is apparently greater than that in hemoperitoneum with intrauterine pregnancy (hIUP; 0.61 +/- 0.18). The median R(P/V) is 4.07 in the EP group versus 0.60 in the hIUP group, with a suggested threshold value of 1.0 for their differential diagnosis. Moreover, the R(P/V) of EP shows the dominant difference between the patients with active bleeding (8.03 +/- 3.29, n = 24) and the patients without active bleeding (4.59 +/- 3.88, n = 16) when the hCG level of venous serum is more than 1500 U/L. CONCLUSION(S): R(P/V) could instantly diagnose ectopic pregnancy and differentiate it from hIUP.
YuDong Wang; Hong Zhao; YinCheng Teng; LiHua Lu; JianQian Tong
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-30
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  702-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, People's Republic of China.
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MeSH Terms
Chorionic Gonadotropin / blood*
Diagnosis, Differential
Early Diagnosis
Hemoperitoneum / diagnosis*,  metabolism*
Pregnancy, Ectopic / blood*,  diagnosis*
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Chorionic Gonadotropin

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