Document Detail

Human chorionic gonadotropin levels in early IVF/ICSI pregnancies are higher in singletons after single embryo transfer compared with singletons after double embryo transfer.
MedLine Citation:
PMID:  18664472     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study is to assess differences in human chorionic gonadotropin (hCG) values between singleton IVF/ICSI pregnancies after elective single (eSET) versus double embryo transfer (DET). METHODS: This is a unicentre, retrospective, non-randomized study of women with eSET or DET in years 2000-2006, giving birth to a singleton child with a birthweight of at least 500 g (N = 790). These women had between 1 and 6 hCG assessments in our centre. Log hCG values from Days 15 to 35 after oocyte pick-up were compared between eSET and DET patients in a multivariate analysis. RESULTS: We compared log hCG values in 456 eSET patients with log hCG values in 334 DET patients. Log hCG values were significantly higher after eSET than after DET from Day 15 until Day 35 after oocyte pick-up (P < 0.001). CONCLUSION: The lower hCG values in early pregnancy are possibly due to a delay in implantation when two embryos are transferred and one of them does not implant, but the exact mechanism is unknown.
I Delbaere; S Vansteelandt; J Gerris; P De Sutter; D De Bacquer; M Temmerman
Publication Detail:
Type:  Journal Article     Date:  2008-07-29
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  23     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2421-6     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Ghent University, De Pintelaan 185 B -9000, Gent, Belgium.
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MeSH Terms
Chorionic Gonadotropin / blood*
Embryo Implantation
Embryo Transfer / methods*
Fertilization in Vitro / methods*
Maternal Age
Multivariate Analysis
Pregnancy, Multiple / statistics & numerical data
Retrospective Studies
Sperm Injections, Intracytoplasmic / methods*
Time Factors
Reg. No./Substance:
0/Chorionic Gonadotropin

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