| Human chorionic gonadotropin levels between 16 and 21 weeks of pregnancy and prediction of pre-eclampsia. | |
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MedLine Citation:
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PMID: 16325185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether levels of beta human choriogonadotropin (beta-hCG) during the second trimester are a predictor of pre-eclampsia. METHODS: A prospective study of 784 women was conducted between their 16th and 20th week of pregnancy. Primigravidas and multigravidas were analyzed separately, and the cutoff point was determined using a receiver operating characteristic curve. The accuracy of beta-hCG levels in the prediction of pre-eclampsia was evaluated. The likelihood ratios were calculated for different levels of beta-hCG in both groups. RESULTS: Pre-eclampsia prevalence was 7.1% among primigravidas and 4.6% among multigravidas. The cutoff concentration was 2.0 MoM in both groups. For primigravidas and multigravidas, respectively, the area below the curve was 0.96 and 0.95; sensitivity was 88.5% and 100%; specificity was 92.0% and 85.6%; positive predictive value was 0.46 and 0.25; and negative predictive value was 0.99 and 1.0. With a cutoff concentration of 2.0 MoM of beta-hCG, the positive likelihood ratio was 11.1 in primigravidas and 6.9 in multigravidas. CONCLUSION: This study shows that measuring levels of beta-hCG during the second trimester of pregnancy is useful in clinical practice to identify pregnant women who will develop pre-eclampsia. |
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Authors:
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J Roiz-Hernández; J de J Cabello-Martínez; M Fernández-Mejía |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-01 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 92 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-20 Completed Date: 2007-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 101-5 Citation Subset: IM |
Affiliation:
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Unidad de Investigación Clínica, Torreón, Coahuila, México. joserioz@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chorionic Gonadotropin / blood* Female Follow-Up Studies Gestational Age Gravidity Humans Pre-Eclampsia / blood, diagnosis* Pregnancy Pregnancy Trimester, Second / blood* Prevalence Prospective Studies ROC Curve Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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