Document Detail

Human chorionic gonadotropin and intravaginal natural progesterone are equally effective for luteal phase support in IVF.
MedLine Citation:
PMID:  11109970     Owner:  NLM     Status:  MEDLINE    
This prospective randomized study compared human chorionic gonadotropin (hCG) and micronized transvaginal progesterone for luteal support in 310 in vitro fertilization (IVF) patients treated with leuprolide acetate and gonadotropins in a long protocol, and showing normal ovarian response. Both treatment groups were homogeneous for age, BMI, stimulation treatment and ovarian response. Pregnancy rates per embryo transfer were not significantly different (33.1% for the hCG group versus 38.7% for the progesterone group). For IVF patients with a normal response to stimulation under pituitary suppression, the use of hCG or progesterone for luteal support does not seem to have any effect on pregnancy rate. The choice of luteal treatment must balance medical hazard and patient convenience, as both therapeutic regimens seem equally effective.
F Martinez; B Coroleu; N Parera; M Alvarez; J M Traver; M Boada; P N Barri
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  14     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-03-22     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  316-20     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Barcelona, Spain.
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MeSH Terms
Administration, Intravaginal
Chorionic Gonadotropin / therapeutic use*
Embryo Transfer
Estradiol / blood
Fertilization in Vitro / methods*
Luteal Phase / physiology*
Progesterone / administration & dosage,  therapeutic use*
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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