Document Detail


Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth.
MedLine Citation:
PMID:  12130577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kaposi's sarcoma is a highly angiogenic, AIDS-associated neoplasm that is more frequent in male than in female patients. Cases of spontaneous regression during pregnancy have been reported and the pregnancy hormone human chorionic gonadotropin (hCG) has shown anti-Kaposi's sarcoma activity in several, but not all, clinical trials. Antiproliferative and proapoptotic activities specific for Kaposi's sarcoma (KS) cells have been shown. We report here further analyses of the anti-KS activity of the hormone and show that urinary hCG, the hCG beta-subunit, the hCG beta-core, and to a lesser extent a recombinant hCG, directly inhibit the activity of matrix metalloproteases of different origin. The hCG hormone also inhibited angiogenesis in vivo in the matrigel sponge assay as well as growth of KS cell xenografts in nude mice. The effect of the pure recombinant hormone dimer on xenograft growth was transient, indicating that the activity of intact hCG alone is not sufficient to overcome the growth potential of this tumor and suggesting that active hCG fragments or other anti-KS activities contribute to the activity of urinary hCG.
Authors:
Ulrich Pfeffer; Davide Bisacchi; Monica Morini; Roberto Benelli; Simona Minghelli; Angelo Vacca; Douglas M Noonan; Adriana Albini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology     Volume:  143     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2002-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3114-21     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of Molecular Biology, National Cancer Research Institute Genova, c/o Advanced Biotechnology Center Genova, Large Rosanna Benzi 10, Genoa 16132, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chorionic Gonadotropin / pharmacology*,  therapeutic use
Humans
Matrix Metalloproteinase 2 / antagonists & inhibitors*
Matrix Metalloproteinase 9 / antagonists & inhibitors*
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Neovascularization, Pathologic / prevention & control*
Protein Subunits
Recombinant Proteins / pharmacology
Sarcoma, Kaposi / blood supply*,  drug therapy,  pathology
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Protein Subunits; 0/Recombinant Proteins; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

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