| Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth. | |
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MedLine Citation:
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PMID: 12130577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kaposi's sarcoma is a highly angiogenic, AIDS-associated neoplasm that is more frequent in male than in female patients. Cases of spontaneous regression during pregnancy have been reported and the pregnancy hormone human chorionic gonadotropin (hCG) has shown anti-Kaposi's sarcoma activity in several, but not all, clinical trials. Antiproliferative and proapoptotic activities specific for Kaposi's sarcoma (KS) cells have been shown. We report here further analyses of the anti-KS activity of the hormone and show that urinary hCG, the hCG beta-subunit, the hCG beta-core, and to a lesser extent a recombinant hCG, directly inhibit the activity of matrix metalloproteases of different origin. The hCG hormone also inhibited angiogenesis in vivo in the matrigel sponge assay as well as growth of KS cell xenografts in nude mice. The effect of the pure recombinant hormone dimer on xenograft growth was transient, indicating that the activity of intact hCG alone is not sufficient to overcome the growth potential of this tumor and suggesting that active hCG fragments or other anti-KS activities contribute to the activity of urinary hCG. |
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Authors:
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Ulrich Pfeffer; Davide Bisacchi; Monica Morini; Roberto Benelli; Simona Minghelli; Angelo Vacca; Douglas M Noonan; Adriana Albini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinology Volume: 143 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-19 Completed Date: 2002-08-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 3114-21 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Molecular Biology, National Cancer Research Institute Genova, c/o Advanced Biotechnology Center Genova, Large Rosanna Benzi 10, Genoa 16132, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chorionic Gonadotropin / pharmacology*, therapeutic use Humans Matrix Metalloproteinase 2 / antagonists & inhibitors* Matrix Metalloproteinase 9 / antagonists & inhibitors* Mice Mice, Inbred C57BL Neoplasm Transplantation Neovascularization, Pathologic / prevention & control* Protein Subunits Recombinant Proteins / pharmacology Sarcoma, Kaposi / blood supply*, drug therapy, pathology Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Protein Subunits; 0/Recombinant Proteins; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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