Document Detail


Human cholecystokinin-A receptor is not an oncofetal protein.
MedLine Citation:
PMID:  10749330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors in human fetal, postnatal, and adult pancreas to determine whether the appearance of CCK-A receptors in pancreatic adenocarcinomas reflected oncofetal antigen or pancreatic neoantigen expression. Messenger ribonucleic acid (mRNA) was isolated from six paraffin-embedded normal pancreatic autopsy specimens ranging in age from 17 weeks postfertilization through 26 days following full-term delivery, and samples of adult human tissues, including pancreas and pancreatic adenocarcinoma. Using reverse transcription-polymerase chain reactions, CCK-B receptor mRNA was expressed in all specimens of normal fetal and postnatal human pancreas, adult pancreas, and pancreatic adenocarcinomas. CCK-A receptor mRNA was selectively expressed only in pancreatic adenocarcinomas. These data suggest that selective CCK-A receptor expression in pancreatic adenocarcinomas reflects neoantigen expression in humans.
Authors:
D S Weinberg; C So; B Ruggeri; S Biswas; M Barber; S Waldman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  45     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-04     Completed Date:  2000-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  538-43     Citation Subset:  AIM; IM    
Affiliation:
Division of Gastroenterology and Hepatology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / chemistry*
Adult
Female
Fetus
Humans
Infant, Newborn
Male
Neoplasm Proteins / analysis*
Pancreas / chemistry
Pancreatic Neoplasms / chemistry*
Polymerase Chain Reaction
RNA, Messenger / analysis
Receptor, Cholecystokinin A
Receptor, Cholecystokinin B
Receptors, Cholecystokinin / analysis*,  genetics
Grant Support
ID/Acronym/Agency:
CA71080/CA/NCI NIH HHS; CA75123/CA/NCI NIH HHS; HL59214/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/RNA, Messenger; 0/Receptor, Cholecystokinin A; 0/Receptor, Cholecystokinin B; 0/Receptors, Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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