Document Detail

Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study.
MedLine Citation:
PMID:  7860762     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of morbidity associated with hyponatremia is postulated to be determined by the state of intracellular cerebral osmolytes. Previously inaccessible, these metabolites can now be quantitated by proton magnetic resonance spectroscopy. An in vivo quantitative assay of osmolytes was performed in 12 chronic hyponatremic patients (mean serum sodium 120 meq/liter) and 10 normal controls. Short echo time proton magnetic resonance spectroscopy of occipital gray and parietal white matter locations revealed dramatic reduction in the concentrations of several metabolites. In gray matter, myo-inositol was most profoundly reduced at 49% of control value. Choline containing compounds were reduced 36%, creatine/phosphocreatine 19%, and N-acetylaspartate 11% from controls. Similar changes were found in white matter. Recovery of osmolyte concentrations was demonstrated in four patients studied 8-14 wk later. These results are consistent with a reversible osmolyte reduction under hypoosmolar stress in the intact human brain and offer novel suggestions for treatment and monitoring of this common clinical event.
J S Videen; T Michaelis; P Pinto; B D Ross
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  95     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-20     Completed Date:  1995-03-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  788-93     Citation Subset:  AIM; IM    
Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, California 91105.
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MeSH Terms
Aged, 80 and over
Aspartic Acid / analogs & derivatives,  metabolism
Brain / metabolism*
Choline / metabolism
Creatine / metabolism
Follow-Up Studies
Hyponatremia / etiology,  metabolism*,  therapy
Inositol / metabolism*
Magnetic Resonance Spectroscopy / methods*
Middle Aged
Periaqueductal Gray / metabolism
Phosphocreatine / metabolism
Reference Values
Sodium / blood
Grant Support
Reg. No./Substance:
56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 67-07-2/Phosphocreatine; 6917-35-7/Inositol; 7440-23-5/Sodium; 997-55-7/N-acetylaspartate
Comment In:
J Clin Invest. 1995 Feb;95(2):441-2   [PMID:  7860723 ]

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