Document Detail

Human cell cultures infected by tumor-inducing and non-tumor-inducing viruses, an electron microscopic study.
MedLine Citation:
PMID:  598460     Owner:  NLM     Status:  MEDLINE    
This study is dealing with the infection patterns of adenovirus type 2 and type 12 on human fibroblast cell lines, KB, WI and MAF. With the exception of Ad -12 leads to WI, many intranuclear viral particles were present. None of these second passages (Ad-2 WI-WI, Ad-12 WI-WI, Ad-2 MAF-MAF, Ad-12 MAF-MAF) was found to have viral production. This indicates that the injections on both WI and MAF cells caused by both Ad-2 and Ad-12 cannot be serially transmitted. However, when these infected cells were used to expose KB cells, significant viral yields were obtained. This shows that the infected cells might still carry the viral specific antigens although no visible virions were observed.
C N Sun; D Hsu; H Pinkerton
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experimentelle Pathologie     Volume:  14     ISSN:  0014-4908     ISO Abbreviation:  Exp Pathol (Jena)     Publication Date:    1977 Jul-Aug
Date Detail:
Created Date:  1978-03-10     Completed Date:  1978-03-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0113124     Medline TA:  Exp Pathol (Jena)     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
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MeSH Terms
Adenoviridae / growth & development*
Cell Line
Cell Nucleus / microbiology*,  ultrastructure
Cytopathogenic Effect, Viral
Inclusion Bodies, Viral*

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