Document Detail


Human cartilage repair with a photoreactive adhesive-hydrogel composite.
MedLine Citation:
PMID:  23303605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Surgical options for cartilage resurfacing may be significantly improved by advances and application of biomaterials that direct tissue repair. A poly(ethylene glycol) diacrylate (PEGDA) hydrogel was designed to support cartilage matrix production, with easy surgical application. A model in vitro system demonstrated deposition of cartilage-specific extracellular matrix in the hydrogel biomaterial and stimulation of adjacent cartilage tissue development by mesenchymal stem cells. For translation to the joint environment, a chondroitin sulfate adhesive was applied to covalently bond and adhere the hydrogel to cartilage and bone tissue in articular defects. After preclinical testing in a caprine model, a pilot clinical study was initiated where the biomaterials system was combined with standard microfracture surgery in 15 patients with focal cartilage defects on the medial femoral condyle. Control patients were treated with microfracture alone. Magnetic resonance imaging showed that treated patients achieved significantly higher levels of tissue fill compared to controls. Magnetic resonance spin-spin relaxation times (T(2)) showed decreasing water content and increased tissue organization over time. Treated patients had less pain compared with controls, whereas knee function [International Knee Documentation Committee (IKDC)] scores increased to similar levels between the groups over the 6 months evaluated. No major adverse events were observed over the study period. With further clinical testing, this practical biomaterials strategy has the potential to improve the treatment of articular cartilage defects.
Authors:
Blanka Sharma; Sara Fermanian; Matthew Gibson; Shimon Unterman; Daniel A Herzka; Brett Cascio; Jeannine Coburn; Alexander Y Hui; Norman Marcus; Garry E Gold; Jennifer H Elisseeff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science translational medicine     Volume:  5     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-06-11     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  167ra6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials
Cartilage / growth & development*
Goats
Humans
Hydrogels*
Magnetic Resonance Imaging
Tissue Adhesives*
Tissue Engineering*
Grant Support
ID/Acronym/Agency:
1K24AR062068-01/AR/NIAMS NIH HHS; 1P01159992-01//PHS HHS; 2R01EB002524-08/EB/NIBIB NIH HHS; 5R01EB005517/EB/NIBIB NIH HHS; K24 AR062068/AR/NIAMS NIH HHS; R01 EB002524/EB/NIBIB NIH HHS; R01AR054005/AR/NIAMS NIH HHS; T32 GM007309/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Hydrogels; 0/Tissue Adhesives
Comments/Corrections
Comment In:
Nat Rev Rheumatol. 2013 Mar;9(3):135   [PMID:  23358508 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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