Document Detail

Human cardiovascular dose-response to supplemental oxygen.
MedLine Citation:
PMID:  17506865     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of the study was to examine the central and peripheral cardiovascular adaptation and its coupling during increasing levels of hyperoxaemia. We hypothesized a dose-related effect of hyperoxaemia on left ventricular performance and the vascular properties of the arterial tree. METHODS: Oscillometrically calibrated arterial subclavian pulse trace data were combined with echocardiographic recordings to obtain non-invasive estimates of left ventricular volumes, aortic root pressure and flow data. For complementary vascular parameters and control purposes whole-body impedance cardiography was applied. In nine (seven males) supine, resting healthy volunteers, aged 23-48 years, data was collected after 15 min of air breathing and at increasing transcutaneous oxygen tensions (20, 40 and 60 kPa), accomplished by a two group, random order and blinded hyperoxemic protocol. RESULTS: Left ventricular stroke volume [86 +/- 13 to 75 +/- 9 mL (mean +/- SD)] and end-diastolic area (19.3 +/- 4.4 to 16.8 +/- 4.3 cm(2)) declined (P < 0.05), and showed a linear, negative dose-response relationship to increasing arterial oxygen levels in a regression model. Peripheral resistance and characteristic impedance increased in a similar manner. Heart rate, left ventricular fractional area change, end-systolic area, mean arterial pressure, arterial compliance or carbon dioxide levels did not change. CONCLUSION: There is a linear dose-response relationship between arterial oxygen and cardiovascular parameters when the systemic oxygen tension increases above normal. A direct effect of supplemental oxygen on the vessels may therefore not be excluded. Proximal aortic and peripheral resistance increases from hyperoxaemia, but a decrease of venous return implies extra cardiac blood-pooling and compensatory relaxation of the capacitance vessels.
Z Bak; F Sjöberg; A Rousseau; I Steinvall; B Janerot-Sjoberg
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-05-17
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  191     ISSN:  1748-1708     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-08     Completed Date:  2007-12-10     Revised Date:  2009-02-03    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-24     Citation Subset:  IM    
Department of Anesthesia and Intensive Care, and Departments of Hand and Plastic Surgery and Burn Intensive Care, University Hospital, Linköping, Sweden.
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MeSH Terms
Blood Pressure
Cardiac Output
Cardiography, Impedance / methods
Cardiovascular System / physiopathology*
Dose-Response Relationship, Drug
Double-Blind Method
Echocardiography, Doppler
Heart Rate
Hyperoxia / physiopathology*
Middle Aged
Oxygen / administration & dosage
Regression Analysis
Stroke Volume
Subclavian Artery
Vascular Resistance
Ventricular Function, Left
Reg. No./Substance:

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