Document Detail

Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?
MedLine Citation:
PMID:  19167460     Owner:  NLM     Status:  MEDLINE    
Established human cancer cell lines are routinely used as experimental models for human cancers. Their validity for such use is analyzed and discussed, with particular focus on thyroid tumors. Although cell lines retain some properties of the cells of origin, from the points of view of their genetics, epigenetics and gene expression, they show clear differences in these properties compared to in vivo tumors. This can be explained by a prior selection of initiating cells and a Darwinian evolution in vitro. The properties of the cell lines are compared to those of the postulated cancer stem cells and their use as models in this regard are discussed. Furthermore, other proper and possible uses of the cell lines are discussed.
W C G van Staveren; D Y Weiss Solís; A Hébrant; V Detours; J E Dumont; C Maenhaut
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-01-08
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1795     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  92-103     Citation Subset:  IM    
IRIBHM, Université Libre de Bruxelles (ULB), Campus Erasme, School of Medicine, Route de Lennik 808, B-1070 Brussels, Belgium.
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MeSH Terms
Cell Line, Tumor* / drug effects
Neoplastic Stem Cells* / drug effects

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