Document Detail

Human caliciviruses in acute gastroenteritis of young children in the community.
MedLine Citation:
PMID:  10804140     Owner:  NLM     Status:  MEDLINE    
Episodes of acute gastroenteritis in prospectively followed children between 2 months and 2 years of age were examined for rotaviruses, enteric adenoviruses, astroviruses, and human caliciviruses, including both Norwalk-like viruses (NLVs) and Sapporo-like viruses (SLVs), using PCR and reverse transcription (RT)-PCR assays. A virus was identified in 60% (502/832) of all episodes and in 85% of the moderately severe or severe episodes. Human caliciviruses were as common as rotaviruses, both being detected in 29% of the cases. NLVs accounted for a 20% etiologic share of all cases; the clinical picture was a moderately severe disease with vomiting as a predominant symptom. SLVs were detected in 9% of the cases, the clinical picture being a mild diarrheal disease. Astroviruses were found in 10% and enteric adenoviruses in 6% of the cases. Diagnosis with PCR and RT-PCR methods increases the detection of all gastroenteritis viruses, particularly human caliciviruses. As a group, human caliciviruses are common causative agents of gastroenteritis in children <2 years of age in Finland, and, of these, NLVs cause more severe disease than SLVs.
X L Pang; S Honma; S Nakata; T Vesikari
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  181 Suppl 2     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S288-94     Citation Subset:  AIM; IM    
Department of Virology and Pediatrics, University of Tampere Medical School, Tampere, Finland.
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MeSH Terms
Acute Disease
Caliciviridae / isolation & purification*
Child, Preschool
Double-Blind Method
Feces / virology
Gastroenteritis / etiology*
Immunoenzyme Techniques
Prospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Rotavirus / isolation & purification

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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