Document Detail


Human brain iron mapping using atlas-based T2 relaxometry.
MedLine Citation:
PMID:  21702065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several in vivo quantitative MRI techniques have been proposed as surrogate measures to map iron content in the human brain. The majority of in vivo quantitative MRI iron mapping methods used the age-dependent iron content data based on postmortem data. In this work, we fused atlas-based human brain volumetry obtained on a large cohort of healthy adults using FreeSurfer with T(2) relaxation time measurements. We provide a brain atlas-based T(2) relaxation time map, which was subsequently used along with published postmortem iron content data to obtain a map of iron content in subcortical and cortical gray matter. We have also investigated the sensitivity of the linear model relating transverse relaxation rate with published iron content to the number of regions used. Our work highlights the challenges encountered on using the simple model along with postmortem data to infer iron content in several brain regions where postmortem iron data are scant (e.g., corpus callosum, amygdale).
Authors:
Khader M Hasan; Indika S Walimuni; Larry A Kramer; Ponnada A Narayana
Related Documents :
22412915 - Prioritizing risks and uncertainties from intentional release of selected category a pa...
22244925 - Identification and classification of conopeptides using profile hidden markov models.
21864085 - Estimation of leaf wetness duration requirements of foliar fungal pathogens with uncert...
21870625 - Calculating ne and ne/n in age-structured populations: a hybrid felsenstein-hill approach.
15825865 - Quantifying errors in spectral estimates of hrv due to beat replacement and resampling.
18924945 - Quantities and units for metabolic processes as a function of time (recommendations 1992).
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-23
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  67     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-29     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  731-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Atlases as Topic
Brain Chemistry*
Brain Mapping / methods*
Female
Humans
Iron / analysis*
Linear Models
Magnetic Resonance Imaging / methods
Male
Middle Aged
Postmortem Changes
Reference Values
Retrospective Studies
Grant Support
ID/Acronym/Agency:
EB002095/EB/NIBIB NIH HHS; R01 NS052505/NS/NINDS NIH HHS; R01 NS052505-04/NS/NINDS NIH HHS; R01-NS052505-04/NS/NINDS NIH HHS; S10 RR19186/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
E1UOL152H7/Iron
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Short echo-time 3D radial gradient-echo MRI using concurrent dephasing and excitation.
Next Document:  Reconstruction of fully three-dimensional high spatial and temporal resolution MR temperature maps f...