| Human brain glycogen metabolism during and after hypoglycemia. | |
| | |
MedLine Citation:
|
PMID: 19502412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We tested the hypotheses that human brain glycogen is mobilized during hypoglycemia and its content increases above normal levels ("supercompensates") after hypoglycemia. RESEARCH DESIGN AND METHODS: We utilized in vivo (13)C nuclear magnetic resonance spectroscopy in conjunction with intravenous infusions of [(13)C]glucose in healthy volunteers to measure brain glycogen metabolism during and after euglycemic and hypoglycemic clamps. RESULTS: After an overnight intravenous infusion of 99% enriched [1-(13)C]glucose to prelabel glycogen, the rate of label wash-out from [1-(13)C]glycogen was higher (0.12 +/- 0.05 vs. 0.03 +/- 0.06 micromol x g(-1) x h(-1), means +/- SD, P < 0.02, n = 5) during a 2-h hyperinsulinemic-hypoglycemic clamp (glucose concentration 57.2 +/- 9.7 mg/dl) than during a hyperinsulinemic-euglycemic clamp (95.3 +/- 3.3 mg/dl), indicating mobilization of glucose units from glycogen during moderate hypoglycemia. Five additional healthy volunteers received intravenous 25-50% enriched [1-(13)C]glucose over 22-54 h after undergoing hyperinsulinemic-euglycemic (glucose concentration 92.4 +/- 2.3 mg/dl) and hyperinsulinemic-hypoglycemic (52.9 +/- 4.8 mg/dl) clamps separated by at least 1 month. Levels of newly synthesized glycogen measured from 4 to 80 h were higher after hypoglycemia than after euglycemia (P <or= 0.01 for each subject), indicating increased brain glycogen synthesis after moderate hypoglycemia. CONCLUSIONS: These data indicate that brain glycogen supports energy metabolism when glucose supply from the blood is inadequate and that its levels rebound to levels higher than normal after a single episode of moderate hypoglycemia in humans. |
| | |
Authors:
|
Gülin Oz; Anjali Kumar; Jyothi P Rao; Christopher T Kodl; Lisa Chow; Lynn E Eberly; Elizabeth R Seaquist |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural Date: 2009-06-05 |
Journal Detail:
|
Title: Diabetes Volume: 58 ISSN: 1939-327X ISO Abbreviation: Diabetes Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-09-01 Completed Date: 2009-09-30 Revised Date: 2010-09-02 |
Medline Journal Info:
|
Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
|
Languages: eng Pagination: 1978-85 Citation Subset: AIM; IM |
Affiliation:
|
Center for MR Research, Department of Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA. gulin@cmrr.umn.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological
/
physiology Adult Blood Glucose / metabolism Brain / metabolism* Carbon Isotopes / diagnostic use Energy Metabolism / physiology* Female Glucose / administration & dosage Glucose Clamp Technique Glycogen / biosynthesis*, metabolism* Humans Hyperinsulinism / metabolism Hypoglycemia / metabolism* Infusions, Intravenous Magnetic Resonance Spectroscopy Male Models, Biological Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
M01RR00400/RR/NCRR NIH HHS; P30NS057091/NS/NINDS NIH HHS; P41RR008079/RR/NCRR NIH HHS; R01 NS035192/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Carbon Isotopes; 50-99-7/Glucose; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Staphylococcus aureus LytSR two-component regulatory system affects biofilm formation.
Next Document: ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility...