Document Detail


Human brain gangliosides: developmental changes from early fetal stage to advanced age.
MedLine Citation:
PMID:  2775765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The developmental profiles of the four major brain gangliosides, GM1, GD1a, GD1b, and GT1b, were examined in human frontal lobe covering the period from 10 fetal weeks to 80 years of age. The ganglioside concentration increased approx. 3-fold from the 10th gestational week to the age of about 5 years. Gangliosides GM1 and GD1a increased 12-15-fold during the same period. The most rapid increase of GM1 and GD1a occurred around term, during the period for dendrite arborization, outgrowth of axons and synaptogenesis. GT1b showed a quite different developmental curve. It was the major ganglioside during the 3rd to 5th gestational month, whereafter its concentration dropped rapidly to term, from which time the concentration then increased up to 50 years of age. Similar curves were found for the other gangliosides of the b-series, GD3, GD2, GD1b and GQ1b. Ganglioside 3'-isoLM1 was a characteristic early fetal ganglioside which dropped rapidly to the 5th gestational month, reached a small peak around term and then disappeared during adulthood. The concentration of gangliosides of the neolacto series was larger than that of the lacto series during the whole developmental period. In the beginning of the second trimester, 3'-LM1 constituted 2% and LD1 10% of total ganglioside sialic acid. The new findings demonstrate more dynamic changes of the ganglioside patterns during development than noted in previous studies.
Authors:
L Svennerholm; K Boström; P Fredman; J E Månsson; B Rosengren; B M Rynmark
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1005     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-17     Completed Date:  1989-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  109-17     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Neurochemistry, Göteborg University, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Brain / embryology,  growth & development,  metabolism*
Child
Child, Preschool
Fetus / metabolism
Gangliosides / isolation & purification,  metabolism*
Humans
Infant
Infant, Newborn
Middle Aged
Chemical
Reg. No./Substance:
0/Gangliosides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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