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Human brain evolution: transcripts, metabolites and their regulators.
MedLine Citation:
PMID:  23324662     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
What evolutionary events led to the emergence of human cognition? Although the genetic differences separating modern humans from both non-human primates (for example, chimpanzees) and archaic hominins (Neanderthals and Denisovans) are known, linking human-specific mutations to the cognitive phenotype remains a challenge. One strategy is to focus on human-specific changes at the level of intermediate phenotypes, such as gene expression and metabolism, in conjunction with evolutionary changes in gene regulation involving transcription factors, microRNA and proximal regulatory elements. In this Review we show how this strategy has yielded some of the first hints about the mechanisms of human cognition.
Authors:
Mehmet Somel; Xiling Liu; Philipp Khaitovich
Publication Detail:
Type:  Journal Article     Date:  2013-01-17
Journal Detail:
Title:  Nature reviews. Neuroscience     Volume:  14     ISSN:  1471-0048     ISO Abbreviation:  Nat. Rev. Neurosci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962781     Medline TA:  Nat Rev Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  112-27     Citation Subset:  IM    
Affiliation:
1] CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China. [2] Department of Integrative Biology, University of California Berkeley, Berkeley, California 94820, USA.
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