Document Detail


Human bocavirus amongst an all-ages population hospitalised with acute lower respiratory infections in Cambodia.
MedLine Citation:
PMID:  22531100     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Human bocavirus (HBoV) is a novel parvovirus that is associated with respiratory and gastrointestinal tract disease.
OBJECTIVES: To investigate the prevalence and genetic diversity of HBoV amongst hospitalized patients with acute lower respiratory infection (ALRI) in Cambodia.
STUDY DESIGN:   Samples were collected from 2773 patients of all ages hospitalised with symptoms of ALRI between 2007 and 2009. All samples were screened by multiplex RT-PCR/PCR for 18 respiratory viruses. All samples positive for HBoV were sequenced and included in this study.
RESULTS: Of the samples tested, 43 (1·5%) were positive for HBoV. The incidence of HBoV did not vary between the consecutive seasons investigated, and HBoV infections were detected year-round. The incidence of HBoV infection was highest in patients aged < 2 years, with pneumonia or bronchopneumonia the most common clinical diagnosis, regardless of age. A total of 19 patients (44%) were co-infected with HBoV and an additional respiratory pathogen. All isolates were classified as HBoV type 1 (HBoV-1). High conservation between Cambodian NP1 and V1V2 gene sequences was observed.
CONCLUSIONS: Human bocavirus infection can result in serious illness, however is frequently detected in the context of viral co-infection. Specific studies are required to further understand the true pathogenesis of HBoV in the context of severe respiratory illness.
Authors:
Alicia Arnott; Sirenda Vong; Sareth Rith; Monica Naughtin; Sowath Ly; Bertrand Guillard; Vincent Deubel; Philippe Buchy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-25
Journal Detail:
Title:  Influenza and other respiratory viruses     Volume:  7     ISSN:  1750-2659     ISO Abbreviation:  Influenza Other Respir Viruses     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2013-07-29     Revised Date:  2013-10-30    
Medline Journal Info:
Nlm Unique ID:  101304007     Medline TA:  Influenza Other Respir Viruses     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-10     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Institut Pasteur in Cambodia, Réseau International des Instituts Pasteur, Phnom Penh, Cambodia.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/JQ618248;  JQ618249;  JQ618250;  JQ618251;  JQ618252;  JQ618253;  JQ618254;  JQ618255;  JQ618256;  JQ618257;  JQ618258;  JQ618259;  JQ618260;  JQ618261;  JQ618262;  JQ618263;  JQ618264;  JQ618265;  JQ618266;  JQ618267;  JQ618268;  JQ618269;  JQ618270;  JQ618271;  JQ618272;  JQ618273;  JQ618274;  JQ618275;  JQ618276;  JQ618277;  JQ618278
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cambodia / epidemiology
Child
Child, Preschool
Cluster Analysis
DNA, Viral / chemistry,  genetics
Female
Genetic Variation
Genotype
Hospitalization
Human bocavirus / classification,  genetics,  isolation & purification*
Humans
Infant
Male
Middle Aged
Molecular Sequence Data
Parvoviridae Infections / epidemiology*,  virology
Prevalence
Respiratory Tract Infections / epidemiology*,  virology
Sequence Analysis, DNA
Young Adult
Chemical
Reg. No./Substance:
0/DNA, Viral

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