Document Detail

Human bile duct carcinoma cell line producing abundant mucin in vitro.
MedLine Citation:
PMID:  2889643     Owner:  NLM     Status:  MEDLINE    
A human bile duct carcinoma cell line, designated OZ, was established from ascitic effusion of a patient who suffered from obstructive jaundice due to the clogging of the common bile duct with mucinous substances secreted by the cancer cells. OZ was found to be capable of producing mucin in vitro and pools of mucin were macroscopically identified on the monolayer of the cells. On the electron micrographs, cell coat type mucin and abundant intracytoplasmic desmosomes were observed. The OZ cells secreted carcinoembryonic antigen in culture and had high enzymatic activity of gamma-glutamyl transpeptidase. The tumor heterotransplanted into nude mice also showed mucin production.
S Homma; S Nagamori; K Fujise; K Yamazaki; S Hasumura; H Sujino; T Matsuura; K Shimizu; H Kameda; K Takaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  22     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-11-24     Completed Date:  1987-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  474-9     Citation Subset:  IM    
First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Adenocarcinoma, Papillary / enzymology,  secretion*,  ultrastructure
Bile Duct Neoplasms / enzymology,  secretion*,  ultrastructure
Carcinoembryonic Antigen / analysis
Cell Line
Microscopy, Electron
Mucins / secretion*
Neoplasm Transplantation
gamma-Glutamyltransferase / metabolism
Reg. No./Substance:
0/Carcinoembryonic Antigen; 0/Mucins; EC

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