| Human bile duct carcinoma cell line producing abundant mucin in vitro. | |
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MedLine Citation:
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PMID: 2889643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A human bile duct carcinoma cell line, designated OZ, was established from ascitic effusion of a patient who suffered from obstructive jaundice due to the clogging of the common bile duct with mucinous substances secreted by the cancer cells. OZ was found to be capable of producing mucin in vitro and pools of mucin were macroscopically identified on the monolayer of the cells. On the electron micrographs, cell coat type mucin and abundant intracytoplasmic desmosomes were observed. The OZ cells secreted carcinoembryonic antigen in culture and had high enzymatic activity of gamma-glutamyl transpeptidase. The tumor heterotransplanted into nude mice also showed mucin production. |
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Authors:
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S Homma; S Nagamori; K Fujise; K Yamazaki; S Hasumura; H Sujino; T Matsuura; K Shimizu; H Kameda; K Takaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterologia Japonica Volume: 22 ISSN: 0435-1339 ISO Abbreviation: Gastroenterol. Jpn. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-11-24 Completed Date: 1987-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0152744 Medline TA: Gastroenterol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 474-9 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Papillary
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enzymology,
secretion*,
ultrastructure Aged Bile Duct Neoplasms / enzymology, secretion*, ultrastructure Carcinoembryonic Antigen / analysis Cell Line Humans Male Microscopy, Electron Mucins / secretion* Neoplasm Transplantation gamma-Glutamyltransferase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carcinoembryonic Antigen; 0/Mucins; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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