Document Detail

Human atrial natriuretic peptide infusion for a neonate with congestive heart failure after total correction of total anomalous pulmonary venous connection.
MedLine Citation:
PMID:  10981857     Owner:  NLM     Status:  MEDLINE    
A successful case of human atrial natriuretic peptide (HANP) infusion therapy for a neonate who developed congestive heart failure (CHF) after total repair of total anomalous pulmonary venous connection was performed on the first day of life. Following 14h of HANP infusion at incremental doses of 0.125-0.25 microg x kg(-1) x min(-1) urine output and hemodynamics dramatically improved. Urine output increased from 1.1 to 10.6 ml/h (p<0.0001) and good urinary output (13.0 ml/h) was maintained even after discontinuation of the infusion. During the infusion, the heart rate decreased from 166 to 152 beats/min (p<0.0001), and the systemic systolic blood pressure increased from 82 to 103 mmHg (p<0.0001). Central venous pressure was not significantly affected by HANP infusion. This is the first successful case of HANP infusion therapy as the first treatment of post-operative pulmonary hypertension in this age group. This therapy can be used safely and may be useful in neonates with CHF resulting from other causes, but more investigation is needed.
M Hamawaki; T Tomino; H Sato; M Imura; T Suzuki; N Hibino
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  64     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-18     Completed Date:  2001-02-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  708-10     Citation Subset:  IM    
Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan.
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MeSH Terms
Atrial Natriuretic Factor / administration & dosage*
Blood Pressure / drug effects
Heart Failure / drug therapy*,  etiology
Heart Rate / drug effects
Hypertension, Pulmonary / drug therapy,  etiology
Infant, Newborn
Pulmonary Veins / abnormalities,  surgery*
Urination / drug effects
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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