Document Detail

Human antroduodenal motility, pyloric closure, and domperidone.
MedLine Citation:
PMID:  6588533     Owner:  NLM     Status:  MEDLINE    
The action of the peripheral dopamine antagonist, domperidone, on human antroduodenal coordination, has been studied in a double-blind study. Thirty dyspeptic patients without antroduodenal pathology were studied at upper alimentary endoscopy, being studied for two 10-minute periods before and after receiving intravenous domperidone (20 mg) or placebo. Antral and proximal duodenal contractions were recorded with Fogarty balloon catheters and pyloric closure recorded as the fall in impedance measured across four small electrodes maintained at the pylorus. Domperidone significantly increased the number of antral contractions. When spontaneous duodenal activity was present, domperidone reduced the number of isolated duodenal contractions (no preceding antral contractions within 10 seconds) without detectably altering the behaviour of the pylorus.
I A Eyre-Brook; R Smallwood; A G Johnson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  92     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1984  
Date Detail:
Created Date:  1984-08-13     Completed Date:  1984-08-13     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  4-7     Citation Subset:  IM    
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MeSH Terms
Domperidone / pharmacology*
Double-Blind Method
Duodenum / drug effects*
Gastrointestinal Motility / drug effects*
Middle Aged
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Pyloric Antrum / drug effects*
Random Allocation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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