| Human antroduodenal motility, pyloric closure, and domperidone. | |
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MedLine Citation:
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PMID: 6588533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The action of the peripheral dopamine antagonist, domperidone, on human antroduodenal coordination, has been studied in a double-blind study. Thirty dyspeptic patients without antroduodenal pathology were studied at upper alimentary endoscopy, being studied for two 10-minute periods before and after receiving intravenous domperidone (20 mg) or placebo. Antral and proximal duodenal contractions were recorded with Fogarty balloon catheters and pyloric closure recorded as the fall in impedance measured across four small electrodes maintained at the pylorus. Domperidone significantly increased the number of antral contractions. When spontaneous duodenal activity was present, domperidone reduced the number of isolated duodenal contractions (no preceding antral contractions within 10 seconds) without detectably altering the behaviour of the pylorus. |
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Authors:
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I A Eyre-Brook; R Smallwood; A G Johnson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 92 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-08-13 Completed Date: 1984-08-13 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 4-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Domperidone / pharmacology* Double-Blind Method Duodenum / drug effects* Endoscopy Female Gastrointestinal Motility / drug effects* Humans Male Middle Aged Muscle Contraction / drug effects Muscle, Smooth / drug effects Pyloric Antrum / drug effects* Random Allocation |
| Chemical | |
Reg. No./Substance:
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57808-66-9/Domperidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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