| Human anti-60 kD heat shock protein autoantibodies are characterized by basic features of natural autoantibodies. | |
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MedLine Citation:
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PMID: 20233685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anti-human Hsp60 autoantibodies--known risk factor of atherosclerosis--were investigated in a mouse model and in samples of healthy subjects: polyreactivity, presence in cord blood samples of healthy newborns and life-long stability were tested. In IgM hybridoma panel from mouse spleens, polyreactivity of anti-Hsp60 autoantibodies was studied. In healthy pregnant women, umbilical vein and maternal blood samples were collected after childbirth, anti-Hsp-60 and -65 IgM and IgG levels were measured. Life-long stability of anti-Hsp-60 levels was studied on healthy patients during 5 years. ELISA was used in all studies. Polyreactivity of IgM clones of newborn mice and lifelong stability of these autoantibodies in healthy adults were established. IgM anti-Hsp60 autoantibodies in cord blood of healthy human infants were present, however, there was no correlation between maternal and cord blood IgM anti-Hsp60 concentrations. It is proposed that presence of anti-Hsp60 autoantibodies--as part of the natural autoantibody repertoire--may be an inherited trait. Level of anti-Hsp60 autoantibodies may be an independent, innate risk factor of atherosclerosis for the adulthood. |
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Authors:
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Szabolcs Varbiro; A Biro; J Cervenak; L Cervenak; M Singh; F Banhidy; A Sebestyen; G F?st; Z Proh?szka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Hungarica Volume: 97 ISSN: 0231-424X ISO Abbreviation: Acta Physiol Hung Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-17 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309201 Medline TA: Acta Physiol Hung Country: Hungary |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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2nd Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, Budapest, Hungary. varbiroszabolcs@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Animals, Newborn Antibodies, Anti-Idiotypic / immunology Autoantibodies / analysis*, blood, chemistry, immunology* Chaperonin 60 / immunology* Female Fetal Blood / immunology Follow-Up Studies Humans Infant, Newborn Male Mice Mice, Inbred BALB C Middle Aged Pregnancy Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Autoantibodies; 0/Chaperonin 60; 0/anti-IgM |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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