| Human albumin synthesis is increased by an ultra-endurance trial. | |
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MedLine Citation:
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PMID: 12544639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to determine whether an ultra-endurance event is a strong stimulus to increase albumin synthesis involved in the process of intravascular albumin mass increase associated with transient hypervolemia. METHODS: The albumin synthetic rate was measured in six young men, 3 d before (C) and on the 1st (R1) and 8th (R8) days of the recovery from an ultra-endurance trial (5 h daily for 4 d). Albumin fractional (FSR) and absolute (ASR) synthetic rate were determined using a primed-constant infusion of [1(-13) C] leucine. Plasma volume (PV) using Evans Blue dye dilution and total body water (TBW) using bioelectrical impedance analysis were measured on C, R1, and R8. RESULTS: On R1 as compared with C: 1). PV (+23.3 +/- 3.2%; P<or= 0.001) and TBW (+4.2 +/- 0.8%; P<or= 0.01) expanded; 2). FSR and ASR both increased from 5.36 +/- 0.46 to 6.86 +/- 0.62%.24 h (+ 29.0 +/- 7.1%; P<or= 0.01) and from 103 +/- 10 to 153 +/- 19 mg.kg body weight (-1).24 h (-1) (+47.5 +/- 6.8%; P<or= 0.01); and 3). plasma albumin and protein masses increased (P<or= 0.05) from 1.92 +/- 0.08 to 2.22 +/- 0.14 g.kg body weight (-1) (i.e., +15.3 +/- 4.9%) and from 3.15 +/- 0.18 to 3.56 +/- 0.21 g.kg body weight (-1) (+13.3 +/- 3.9%), respectively. By R8, all these parameters had returned to their control levels except for albumin mass (1.73 +/- 0.08 g.kg body weight(-1), which was lower than C ( P<or= 0.05). CONCLUSION: The increase in the albumin synthetic rate the day after an ultra-endurance trial is a major event associated with a greater circulating protein mass. The impact of exercise on albumin synthesis has disappeared 8 d later, as did PV and total protein mass expansion. |
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Authors:
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Isabelle Mischler; Yves Boirie; Pierre Gachon; Vincent Pialoux; Remi Mounier; Paulette Rousset; Jean Coudert; Nicole Fellmann |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 35 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-24 Completed Date: 2003-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 75-81 Citation Subset: IM; S |
Affiliation:
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Laboratoire de Physiologie-Biologie du Sport, Faculté de Médecine, Université d'Auvergne, Clermont-Ferrand, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albumins / biosynthesis* Body Water Body Weight Electric Impedance Humans Male Physical Endurance / physiology* Plasma Volume |
| Chemical | |
Reg. No./Substance:
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0/Albumins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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