| Human airway secretory cells during development and in mature airway epithelium. | |
| | |
MedLine Citation:
|
PMID: 1577157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The combined secretions of distinct secretory cells of the airway lining mucosa serve to keep the inspired air moist and free of potentially harmful dust particles, organisms and adsorbed gases. Apart from their role in protecting the respiratory zone of the lung, mucus-secreting cells act as pluripotential stem cells during foetal development and, in the adult, following mucosal injury. The variety of secretory cells include the mucous and serous cells of the surface and glandular epithelium, the non-ciliated bronchiolar (Clara) cell and the less frequent dense-core granulated (neuroendocrine) cell. The last-mentioned is the first type to differentiate at about 10 weeks of gestation; mucus-secreting cells are present from the 13th week of gestation, when mature ciliated cells are already present, and Clara cells begin to mature during the 19th week of human development. The alteration of secretory cell number and chemical composition of their secretions during the second trimester of foetal life is similar to that which occurs in chronic bronchitis in the adult. However, in hypersecretory disease the extent and site of the major change appear to be inappropriate to the defence of the lung. |
| | |
Authors:
|
P K Jeffery; D Gaillard; S Moret |
Related Documents
:
|
3004707 - Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carc... 1550257 - Ontogeny of surfactant secretion in type ii pneumocytes from fetal, newborn, and adult ... 12875367 - Alveolar epithelial cell-macrophage interactions affect oxygen-stimulated interleukin-8... 810507 - An ontogenic study of histamine and mast cells in the fetal rhesus monkey. 2092047 - Mercuric chloride inhibition of leucocyte migration. 15100367 - Local actions of endogenous angiotensin ii in injured glomeruli. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The European respiratory journal Volume: 5 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1992 Jan |
Date Detail:
|
Created Date: 1992-06-10 Completed Date: 1992-06-10 Revised Date: 2013-05-23 |
Medline Journal Info:
|
Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 93-104 Citation Subset: IM |
Affiliation:
|
NHLI, Royal Brompton Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Epithelial Cells Epithelium / embryology, growth & development, secretion, ultrastructure Humans Lung / embryology Mucus / secretion Respiratory System / cytology, embryology, growth & development, secretion*, ultrastructure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Within-breath variations of forced oscillation resistance in healthy subjects.
Next Document: NADH: ubiquinone oxidoreductase from bovine heart mitochondria. A fourth nuclear encoded subunit wit...