Document Detail


Human airway secretory cells during development and in mature airway epithelium.
MedLine Citation:
PMID:  1577157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The combined secretions of distinct secretory cells of the airway lining mucosa serve to keep the inspired air moist and free of potentially harmful dust particles, organisms and adsorbed gases. Apart from their role in protecting the respiratory zone of the lung, mucus-secreting cells act as pluripotential stem cells during foetal development and, in the adult, following mucosal injury. The variety of secretory cells include the mucous and serous cells of the surface and glandular epithelium, the non-ciliated bronchiolar (Clara) cell and the less frequent dense-core granulated (neuroendocrine) cell. The last-mentioned is the first type to differentiate at about 10 weeks of gestation; mucus-secreting cells are present from the 13th week of gestation, when mature ciliated cells are already present, and Clara cells begin to mature during the 19th week of human development. The alteration of secretory cell number and chemical composition of their secretions during the second trimester of foetal life is similar to that which occurs in chronic bronchitis in the adult. However, in hypersecretory disease the extent and site of the major change appear to be inappropriate to the defence of the lung.
Authors:
P K Jeffery; D Gaillard; S Moret
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The European respiratory journal     Volume:  5     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-10     Completed Date:  1992-06-10     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  93-104     Citation Subset:  IM    
Affiliation:
NHLI, Royal Brompton Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Epithelial Cells
Epithelium / embryology,  growth & development,  secretion,  ultrastructure
Humans
Lung / embryology
Mucus / secretion
Respiratory System / cytology,  embryology,  growth & development,  secretion*,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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