Document Detail


Human adrenocortical carcinoma cell lines.
MedLine Citation:
PMID:  21924324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human adrenal cortex secretes mineralocorticoids, glucocorticoids and adrenal androgens. These steroids are produced from unique cell types located within the three distinct zones of the adrenal cortex. Disruption of adrenal steroid production results in a variety of diseases that can lead to hypertension, metabolic syndrome, infertility and androgen excess. The adrenal cortex is also a common site for the development of adenomas, and rarely the site for the development of carcinomas. The adenomas can lead to diseases associated with adrenal steroid excess, while the carcinomas are particularly aggressive and have a poor prognosis. In vitro cell culture models provide important tools to examine molecular and cellular mechanisms controlling both the normal and pathologic function of the adrenal cortex. Herein, we discuss currently available human adrenocortical carcinoma cell lines and their use as model systems for adrenal studies.
Authors:
Tao Wang; William E Rainey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-09-05
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  351     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-11     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adenoma* / metabolism,  pathology
Adrenal Cortex / metabolism,  pathology
Adrenal Cortex Neoplasms* / metabolism,  pathology
Androgens / secretion
Cell Line, Tumor* / metabolism,  pathology
Glucocorticoids / secretion
Humans
Mineralocorticoids / secretion
Models, Biological*
Grant Support
ID/Acronym/Agency:
DK43140/DK/NIDDK NIH HHS; R01 DK043140/DK/NIDDK NIH HHS; R01 DK043140-19/DK/NIDDK NIH HHS; R01 DK069950/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Androgens; 0/Glucocorticoids; 0/Mineralocorticoids
Comments/Corrections

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