| Human adrenocortical carcinoma cell lines. | |
| | |
MedLine Citation:
|
PMID: 21924324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The human adrenal cortex secretes mineralocorticoids, glucocorticoids and adrenal androgens. These steroids are produced from unique cell types located within the three distinct zones of the adrenal cortex. Disruption of adrenal steroid production results in a variety of diseases that can lead to hypertension, metabolic syndrome, infertility and androgen excess. The adrenal cortex is also a common site for the development of adenomas, and rarely the site for the development of carcinomas. The adenomas can lead to diseases associated with adrenal steroid excess, while the carcinomas are particularly aggressive and have a poor prognosis. In vitro cell culture models provide important tools to examine molecular and cellular mechanisms controlling both the normal and pathologic function of the adrenal cortex. Herein, we discuss currently available human adrenocortical carcinoma cell lines and their use as model systems for adrenal studies. |
| | |
Authors:
|
Tao Wang; William E Rainey |
Related Documents
:
|
8336154 - Rat-1 fibroblasts engineered with gad65 and gad67 cdnas in retroviral vectors produce a... 19147554 - Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid... 8224004 - Formation of ductular structures in vitro by rat pancreatic epithelial oval cells. 9438224 - The effect of diet on the vervet monkey endocrine pancreas. 17198874 - All-trans retinoic acid induces proliferation of an irradiated stem cell supporting str... 16599554 - Enhanced biodegradation of toxic organophosphate compounds using recombinant escherichi... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-09-05 |
Journal Detail:
|
Title: Molecular and cellular endocrinology Volume: 351 ISSN: 1872-8057 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-20 Completed Date: 2012-06-11 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 58-65 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Physiology, Georgia Health Sciences University, Augusta, GA 30912, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoma*
/
metabolism,
pathology Adrenal Cortex / metabolism, pathology Adrenal Cortex Neoplasms* / metabolism, pathology Androgens / secretion Cell Line, Tumor* / metabolism, pathology Glucocorticoids / secretion Humans Mineralocorticoids / secretion Models, Biological* |
| Grant Support | |
ID/Acronym/Agency:
|
DK43140/DK/NIDDK NIH HHS; R01 DK043140-19/DK/NIDDK NIH HHS; R01 DK069950/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Androgens; 0/Glucocorticoids; 0/Mineralocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Potential link between alpha 1 anti-trypsin and PAR-2 in the prevention of beta cell dysfunction.
Next Document: Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model.