Document Detail

Human VNTR mutation and sex.
MedLine Citation:
PMID:  8400715     Owner:  NLM     Status:  MEDLINE    
Seven hypervariable VNTR loci have been studied in about 1200 parent/child pairs about equally divided between the sexes. Mutations were observed with all seven probes, the total number being 71. Fourty-four of these involved increased fragment length. Gains in fragment length were on average larger than losses. These findings indicate that mutation might be a basis for evolutionary expansion of VNTR fragment length. For five probes YNH24 (D2S44), MS31 (D7S21), g3 (D7S22), MS43A (D12S11), and CMM101 (D14S13), mutation rates were relatively low (less than 1%) with no obvious sex difference. MS1 (D1S7) mutation frequencies were substantially higher, with a tendency towards a higher paternal than maternal mutation rate (5.4% and 2.0%, respectively). The probe B6.7 (provisionally assigned to chromosome 20) exhibits about five times higher paternal than maternal mutation rates. The mutation rate of 7.6% in paternal chromosomes is among the highest reported in any VNTR locus. These findings could indicate that while low-mutant VNTRs might reflect meiotic crossover, mutation events in high-mutant loci could more often be caused by other mechanisms during cell division.
B Olaisen; M Bekkemoen; P Hoff-Olsen; P Gill
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  EXS     Volume:  67     ISSN:  1023-294X     ISO Abbreviation:  EXS     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-05     Completed Date:  1993-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204529     Medline TA:  EXS     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Institute of Forensic Medicine, University of Oslo.
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MeSH Terms
DNA / genetics
DNA Fingerprinting
Molecular Probes
Repetitive Sequences, Nucleic Acid*
Sex Characteristics
Reg. No./Substance:
0/Molecular Probes; 9007-49-2/DNA

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