| Human Vγ9Vδ2-T cells efficiently kill influenza virus-infected lung alveolar epithelial cells. | |
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MedLine Citation:
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PMID: 23353835 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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γδ-T cells play an indispensable role in host defense against different viruses, including influenza A virus. However, whether these cells have cytotoxic activity against influenza virus-infected lung alveolar epithelial cells and subsequently contribute to virus clearance remains unknown. Using influenza virus-infected A549 cells, human lung alveolar epithelial cells, we investigated the cytotoxic activity of aminobisphosphonate pamidronate (PAM)-expanded human Vγ9Vδ2-T cells and their underlying mechanisms. We found that PAM could selectively activate and expand human Vγ9Vδ2-T cells. PAM-expanded human Vγ9Vδ2-T cells efficiently killed influenza virus-infected lung alveolar epithelial cells and inhibited virus replication. The cytotoxic activity of PAM-expanded Vγ9Vδ2-T cells was dependent on cell-to-cell contact and required NKG2D activation. Perforin-granzyme B, tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas-Fas ligand (FasL) pathways were involved in their cytotoxicity. Our study suggests that targeting γδ-T cells by PAM can potentially offer an alternative option for the treatment of influenza virus.Cellular & Molecular Immunology advance online publication, 28 January 2013; doi:10.1038/cmi.2012.70. |
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Authors:
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Hong Li; Zheng Xiang; Ting Feng; Jinrong Li; Yinping Liu; Yingying Fan; Qiao Lu; Zhongwei Yin; Meixing Yu; Chongyang Shen; Wenwei Tu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
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Title: Cellular & molecular immunology Volume: - ISSN: 2042-0226 ISO Abbreviation: Cell. Mol. Immunol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101242872 Medline TA: Cell Mol Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Joint Research Center of West China Second University Hospital of Sichuan University and Department of Paediatrics and Adolescent Medicine of University of Hong Kong, Sichuan University, Chengdu 610041, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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