Document Detail


Human Umbilical Cord Stem Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Immunoinflammation and Remyelination.
MedLine Citation:
PMID:  23140594     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Multiple sclerosis (MS) is an irreversible and demyelinating disease of the central nervous system (CNS), in part influenced by chronic inflammation. There is no proven effective therapy to stop the pathological progression of MS, although suppressing the immune system to control the inflammatory response may improve the clinical performance acutely. Here, we found that mesenchymal stem cells from human umbilical cord (hUC-MSCs) could restore behavioral functions and attenuate the histopathological deficits of experimental autoimmune encephalomyelitis (EAE) mice over the long-term (i.e., 50 days) by suppression of perivascular immune cell infiltrations and reduction in both demyelination and axonal injury in the spinal cord. These findings suggest that transplantation of hUC-MSCs may be a potential therapy for MS.
Authors:
Rong Liu; Zhuo Zhang; Zhengjuan Lu; Cesario V Borlongan; Jie Pan; Junhao Chen; Lai Qian; Zhuo Liu; Lin Zhu; Jun Zhang; Yun Xu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Stem cells and development     Volume:  -     ISSN:  1557-8534     ISO Abbreviation:  Stem Cells Dev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197107     Medline TA:  Stem Cells Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Affiliated Drum Tower Hospital of Nanjing University Medical School, Department of Neurology, nanjing, China; liurong200800@163.com.
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