Document Detail


Human telomeric DNA sequence-specific cleaving by G-quadruplex formation.
MedLine Citation:
PMID:  19209856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telomere is an emerging target for the treatment of human cancers. Here, we report a structure-based approach to sequence-specific cleaving of human telomeric DNA by G-quadruplex formation. Oligonucleotide with multiphosphonate [DNA-EDTP.Ce(IV)] at the 5' end binds to human telomere DNA by G-quadruplex formation and causes a sequence-specific strand break. These results provide the first proof of concept for targeting the human telomere DNA based on G-quadruplex formation, and this may serve as a starting point for the design of more efficient telomere sequence-specific cleaving reagents by G-quadruplex formation.
Authors:
Yan Xu; Yuta Suzuki; Tuomas Lönnberg; Makoto Komiyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  131     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2871-4     Citation Subset:  IM    
Affiliation:
Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. xuyan@mkomi.rcast.u-tokyo.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Cerium / chemistry
DNA / chemistry*,  genetics,  metabolism
DNA Probes / chemistry
Ethylenediamines / chemistry
G-Quadruplexes*
Humans
Kinetics
Phosphonic Acids / chemistry
Sequence Analysis, DNA / methods
Telomere / chemistry*,  genetics,  metabolism
Chemical
Reg. No./Substance:
0/DNA Probes; 0/Ethylenediamines; 0/Phosphonic Acids; 0/ethylenediaminetetrakis(methylphosphonic) acid; 7440-45-1/Cerium; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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