| Human T cells directed to seasonal influenza A virus cross-react with A(H1N1)pdm09 and swine origin triple reassortant H3N2 influenza viruses. | |
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MedLine Citation:
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PMID: 23152369 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Virus-specific CD8+ T cells contribute to protective immunity against influenza A virus infections. Since the majority of these cells are directed to conserved viral proteins, they may afford protection against influenza A viruses of various subtypes. In the present study, we assessed the cross-reactivity of human CD8+ T lymphocytes, induced by infection with seasonal A(H1N1) or A(H3N2) influenza viruses, with 2009 pandemic influenza A/H1N1 virus (A(H1N1)pdm09) and swine origin triple reassortant A(H3N2) (A(H3N2)v) viruses that currently cause an increasing number of human cases in the USA. We demonstrated that CD8+ T cells induced after seasonal influenza A virus infections exert lytic activity and produce IFN-γ upon in vitro restimulation with A(H1N1)pdm09 and A(H3N2)v influenza A viruses. Furthermore, CD8+ T cells directed to A(H1N1)pdm09 virus displayed a high degree of cross-reactivity with A(H3N2)v viruses. It was concluded that cross-reacting T cells have the potential to afford protective immunity against A(H1N1)pdm09 viruses during the pandemic and offer some degree of protection against infection with A(H3N2)v viruses. |
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Authors:
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Marine L B Hillaire; Stella E Vogelzang-van Trierum; Joost H M C Kreijtz; Gerrie de Mutsert; Ron A M Fouchier; Albert D M E Osterhaus; Guus F Rimmelzwaan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: The Journal of general virology Volume: - ISSN: 1465-2099 ISO Abbreviation: J. Gen. Virol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Erasmus MC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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