Document Detail


Human T cells directed to seasonal influenza A virus cross-react with A(H1N1)pdm09 and swine origin triple reassortant H3N2 influenza viruses.
MedLine Citation:
PMID:  23152369     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Virus-specific CD8+ T cells contribute to protective immunity against influenza A virus infections. Since the majority of these cells are directed to conserved viral proteins, they may afford protection against influenza A viruses of various subtypes. In the present study, we assessed the cross-reactivity of human CD8+ T lymphocytes, induced by infection with seasonal A(H1N1) or A(H3N2) influenza viruses, with 2009 pandemic influenza A/H1N1 virus (A(H1N1)pdm09) and swine origin triple reassortant A(H3N2) (A(H3N2)v) viruses that currently cause an increasing number of human cases in the USA. We demonstrated that CD8+ T cells induced after seasonal influenza A virus infections exert lytic activity and produce IFN-γ upon in vitro restimulation with A(H1N1)pdm09 and A(H3N2)v influenza A viruses. Furthermore, CD8+ T cells directed to A(H1N1)pdm09 virus displayed a high degree of cross-reactivity with A(H3N2)v viruses. It was concluded that cross-reacting T cells have the potential to afford protective immunity against A(H1N1)pdm09 viruses during the pandemic and offer some degree of protection against infection with A(H3N2)v viruses.
Authors:
Marine L B Hillaire; Stella E Vogelzang-van Trierum; Joost H M C Kreijtz; Gerrie de Mutsert; Ron A M Fouchier; Albert D M E Osterhaus; Guus F Rimmelzwaan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  The Journal of general virology     Volume:  -     ISSN:  1465-2099     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Erasmus MC.
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