Document Detail

Human T-cell lymphotropic virus type I and neurologic disease in Panama, 1985 and 1986.
MedLine Citation:
PMID:  2346389     Owner:  NLM     Status:  MEDLINE    
Human T-cell lymphotropic virus type I (HTLV-I) causes adult T-cell leukemia and has recently been associated with HTLV-associated myelopathy/tropical spastic paraparesis. The HTLV-I is endemic throughout the Caribbean basin and parts of South America, and HTLV-associated myelopathy/tropical spastic paraparesis also seems to be common in this area. This 2-year study, 1985 and 1986, was designed to evaluate the occurrence of HTLV-I infection in all newly diagnosed cases of selected neurologic diseases in Panama City, Panama. Six (8%) of 71 patients had antibody to HTLV-I detected by immunofluorescence, enzyme-linked immunosorbent assay, radioimmunoassay, and Western blot assays; 5 patients' conditions were diagnosed as spastic paraparesis, and all 5 were seropositive and also had HTLV-I antibody in cerebrospinal fluid. The remaining seropositive patient had multiple sclerosis, and no antibody was detected in her cerebrospinal fluid. Clinical and electrophysiologic studies indicated that HTLV-I-associated spastic paraparesis is a multifocal, primarily demyelinating disease that principally involves the spinal cord.
F Gracia; W C Reeves; P H Levine; M Cuevas; L Castillo; R Chavarría; V Grimaldo; E Triana; J R Arosemena; W A Blattner
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of neurology     Volume:  47     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-06-29     Completed Date:  1990-06-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  634-9     Citation Subset:  AIM; IM; X    
Neurology Service, Santo Tomas Hospital, Panama City, Panama.
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MeSH Terms
Central Nervous System Diseases / complications,  epidemiology
HTLV-I Antibodies / analysis
HTLV-I Infections / complications,  epidemiology*,  genetics
Middle Aged
Panama / epidemiology
Paraparesis, Tropical Spastic / complications,  epidemiology
Grant Support
Reg. No./Substance:
0/HTLV-I Antibodies

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