Document Detail

Human T-cell lymphotropic virus type 1 (HTLV-1) and lymphoid malignancies in Dominica: a seroprevalence study.
MedLine Citation:
PMID:  15551358     Owner:  NLM     Status:  MEDLINE    
Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in certain regions of the world where it is associated with lymphoid malignancies. Herein we aim to describe the seroprevalence of HTLV-1 in lymphoid malignancies in Dominica. We carried out a 10-year retrospective study of histologically proven hematologic malignancies and HTLV-1 seropositivity at the Princess Margaret Hospital, Dominica. Ninety-eight cases were reviewed (59% males, 41% females), ranging in age from 3 to 91 years. HTLV-1 was seropositive in 38.6% (31/80) of all hematologic malignancies. Three of 6 cases of Hodgkin disease (50%), 16 of 36 (44.4%) of non-Hodgkin lymphoma, and 3 out of 8 unclassified lymphomas (37.5%) were seropositive; all 6 cases (100%) of acute adult T-cell leukemia/lymphoma (ATLL) were seropositive. One case each of chronic lymphocytic leukemia and myeloproliferative disorder was seropositive. HTLV-1-seropositive lymphomas presented at a younger age than did seronegative cases. Thus, HTLV-1 is significantly associated with lymphoid malignancies in Dominica, and further studies are needed before a causal relationship with Hodgkin disease can be established.
Olayinka A Adedayo; Sani M Shehu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  77     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-29     Completed Date:  2005-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-9     Citation Subset:  IM    
Copyright Information:
2004 Wiley-Liss, Inc.
Ross University School of Medicine, Dominica, West Indies.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Deltaretrovirus Antibodies / analysis
Dominica / epidemiology
HTLV-I Infections / diagnosis,  epidemiology*
Human T-lymphotropic virus 1 / isolation & purification*
Lymphoma / diagnosis,  epidemiology*
Middle Aged
Retrospective Studies
Seroepidemiologic Studies
Reg. No./Substance:
0/Deltaretrovirus Antibodies

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