Document Detail

Human susceptibility to legionnaires' disease.
MedLine Citation:
PMID:  23150419     Owner:  NLM     Status:  MEDLINE    
Legionella pneumophila is a facultative intracellular pathogen that is an important cause of pneumonia. Although host factors that may predispose to acquisition of Legionnaire's Disease (LD) include comorbid illnesses (e.g., diabetes, chronic lung disease), age, male sex, and smoking, many individuals have no identifiable risk factors. Some studies suggest that genetic factors may enhance susceptibility to LD. In this chapter we discuss current techniques and scientific methods to identify genetic susceptibility factors. These genetic studies provide insight into the human immune response to intracellular pathogens and may improve strategies for treatment and vaccine development.
William R Berrington; Thomas R Hawn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  954     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-19     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-51     Citation Subset:  IM    
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MeSH Terms
Genetic Predisposition to Disease*
Genetic Variation
Genotyping Techniques
Legionella pneumophila / pathogenicity*
Legionnaires' Disease / genetics*
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Grant Support

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