Document Detail


Human SGBS cells - a unique tool for studies of human fat cell biology.
MedLine Citation:
PMID:  20054179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human Simpson-Golabi-Behmel syndrome (SGBS) preadipocyte cell strain provides a unique and useful tool for studies of human adipocyte biology. The cells originate from an adipose tissue specimen of a patient with SGBS. They are neither transformed nor immortalized, and provide an almost unlimited source due to their ability to proliferate for up to 50 generations with retained capacity for adipogenic differentiation. So far, the cells have been used for a number of studies on adipose differentiation, adipocyte glucose uptake, lipolysis, apoptosis, regulation of expression of adipokines, and protein translocation. The cells are efficiently differentiated in the presence of PPARgammaagonists and in the absence of serum and albumin. SGBS adipocytes respond to insulin stimulation by increasing glucose uptake several-fold (EC50 approximately 100 pmol/l), and by very effectively inhibiting (IC50 approximately 10 pmol/l) catecholamine-stimulated lipolysis.
Authors:
Pamela Fischer-Posovszky; Felicity S Newell; Martin Wabitsch; Hans E Tornqvist
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-08-14
Journal Detail:
Title:  Obesity facts     Volume:  1     ISSN:  1662-4025     ISO Abbreviation:  Obes Facts     Publication Date:  2008  
Date Detail:
Created Date:  2010-01-07     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469429     Medline TA:  Obes Facts     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  184-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 S. Karger AG, Basel.
Affiliation:
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Germany.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / physiopathology
Adipocytes / cytology*,  physiology*
Adipose Tissue / cytology*,  physiology*
Animals
Cell Line
Humans
Obesity / physiopathology*
Syndrome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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