| Human Radiation Dose Estimation of 11C-CFT Using Whole-Body PET. | |
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MedLine Citation:
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PMID: 23154473 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: C-Labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane (C-CFT) is a commonly used positron emission tomography (PET) tracer for dopamine transporters imaging. The present study estimated human radiation absorbed doses of C-CFT based on whole-body PET imaging in healthy subjects. METHODS: Whole-body PET was performed on 6 subjects after injection of 472.06 ± 116.47 MBq of C-CFT. 7 Frames were acquired for about 70 min in 7 segments of the body. Regions of interest were drawn on PET images of source organs. Residence time was calculated as the area under the time-activity curve. Radiation dosimetry was calculated from organ residence time using the medical internal radiation dosimetry (MIDR) method. RESULTS: The organs with the highest radiation-absorbed doses were the urinary bladder, followed the spleen, pancreas, kidneys, and stomach. The dose-limiting critical organ was the urinary bladder. The effective dose was 8.89E-03 mSv/MBq (22.9 mrem/mCi). Biexponential fitting of mean bladder activity demonstrated that 18% of activity was excreted via the urine. CONCLUSIONS: The potential radiation risks of C-CFT associated with in this study are well within accepted limits. C-CFT demonstrates a favorable radiation dose profile in humans and allows multiple PET examinations on the same subject per year. |
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Authors:
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Tingting Huang; Hongliang Wang; Ganghua Tang; Xiang Liang; Huaifu Deng; Chang Yi; Xiangsong Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 37 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1159-62 Citation Subset: IM |
Affiliation:
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From the Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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