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Human Radiation Dose Estimation of 11C-CFT Using Whole-Body PET.
MedLine Citation:
PMID:  23154473     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: C-Labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane (C-CFT) is a commonly used positron emission tomography (PET) tracer for dopamine transporters imaging. The present study estimated human radiation absorbed doses of C-CFT based on whole-body PET imaging in healthy subjects.
METHODS: Whole-body PET was performed on 6 subjects after injection of 472.06 ± 116.47 MBq of C-CFT. 7 Frames were acquired for about 70 min in 7 segments of the body. Regions of interest were drawn on PET images of source organs. Residence time was calculated as the area under the time-activity curve. Radiation dosimetry was calculated from organ residence time using the medical internal radiation dosimetry (MIDR) method.
RESULTS: The organs with the highest radiation-absorbed doses were the urinary bladder, followed the spleen, pancreas, kidneys, and stomach. The dose-limiting critical organ was the urinary bladder. The effective dose was 8.89E-03 mSv/MBq (22.9 mrem/mCi). Biexponential fitting of mean bladder activity demonstrated that 18% of activity was excreted via the urine.
CONCLUSIONS: The potential radiation risks of C-CFT associated with in this study are well within accepted limits. C-CFT demonstrates a favorable radiation dose profile in humans and allows multiple PET examinations on the same subject per year.
Authors:
Tingting Huang; Hongliang Wang; Ganghua Tang; Xiang Liang; Huaifu Deng; Chang Yi; Xiangsong Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  37     ISSN:  1536-0229     ISO Abbreviation:  Clin Nucl Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1159-62     Citation Subset:  IM    
Affiliation:
From the Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
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