| Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. | |
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MedLine Citation:
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PMID: 20934517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Helicases use the energy of ATP hydrolysis to separate double-stranded nucleic acids to facilitate essential processes such as replication, recombination, transcription and repair. This article focuses on the human RECQ helicase gene and protein family. Loss of function of three different members has been shown to cause Bloom syndrome (BS), Werner syndrome (WS) and Rothmund-Thomson syndrome (RTS). This article outlines clinical and cellular features of these cancer predisposition syndromes, and discusses their pathogenesis in light of our understanding of RECQ helicase biochemical activities and in vivo functions. I also discuss the emerging role for RECQ helicases as predictors of disease risk and the response to therapy. |
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Authors:
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Raymond J Monnat |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-10-08 |
Journal Detail:
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Title: Seminars in cancer biology Volume: 20 ISSN: 1096-3650 ISO Abbreviation: Semin. Cancer Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-03-24 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 9010218 Medline TA: Semin Cancer Biol Country: England |
Other Details:
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Languages: eng Pagination: 329-39 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA. monnat@u.washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bloom Syndrome
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genetics DNA / genetics, metabolism* DNA Repair DNA Replication Genomic Instability Humans Mutagenesis* Mutation Neoplasms / genetics* RecQ Helicases / genetics*, metabolism* Rothmund-Thomson Syndrome / genetics Telomere Werner Syndrome / genetics |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA077852-13/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA; EC 3.6.1.-/RecQ Helicases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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