Document Detail


Human papillomavirus infection in women in Puerto Rico: agreement between physician-collected and self-collected anogenital specimens.
MedLine Citation:
PMID:  23422638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study aimed to describe the prevalence and concordance between cervical and anal human papillomavirus (HPV) infection and compare cervicovaginal and anal self-collection methods for HPV testing between physician and self-collected specimens in women in Puerto Rico.
MATERIALS AND METHODS: Specimens for HPV-DNA testing were obtained from 100 women aged 18 to 34 years attending a general gynecology clinic for a routine Pap smear. Human papillomavirus testing was performed using polymerase chain reaction MY09/MY11 primers. Positive samples were typed for 39 genotypes. Agreement between sampling methods was determined by percent agreement and the κ statistic.
RESULTS: For the 39 genotypes evaluated, 38.4% (38/99) of cervicovaginal and 33.7% (30/89) of anal physician-collected samples were HPV+, whereas 35.1% (34/97) of cervicovaginal and 32.0% (31/97) of anal self-collected samples were positive. Human papillomavirus type 16 was the most common type identified in the cervix (8.3%, 8/97) and the anus (5.6%, 5/89) of physician-collected samples, with similar prevalence in self-collected samples. Concordance between cervical and anal HPV infection was high (>90%) for all types evaluated. There was a strong percent agreement between physician- and self-collected cervicovaginal and anal samples (>95% for all HPV types) and good to excellent agreement (κ > 0.60) for most HPV types.
CONCLUSIONS: The clinic-based prevalence of anal and cervicovaginal HPV infection was high, with a strong concordance between cervical and anal infection and good to excellent agreement between physician- and self-collected samples. This study supports the feasibility of using cervical and anal self-sampling methods in future population-based studies of HPV infection in Puerto Rico and as an HPV screening method in women.
Authors:
Ana Patricia Ortiz; Josefina Romaguera; Cynthia M Pérez; Yomayra Otero; Marievelisse Soto-Salgado; Keimari Méndez; Yari Valle; Maria Da Costa; Erick Suarez; Joel Palefsky; Guillermo Tortolero-Luna
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of lower genital tract disease     Volume:  17     ISSN:  1526-0976     ISO Abbreviation:  J Low Genit Tract Dis     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-25     Completed Date:  2013-09-02     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9704963     Medline TA:  J Low Genit Tract Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Ambulatory Care / methods*
Anus Diseases / diagnosis,  epidemiology
DNA, Viral / genetics,  isolation & purification
Female
Genotype
Humans
Papillomaviridae / classification,  genetics,  isolation & purification*
Papillomavirus Infections / diagnosis*,  epidemiology*
Prevalence
Puerto Rico / epidemiology
Self Administration / methods*
Specimen Handling / methods*
Uterine Cervical Diseases / diagnosis,  epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
1U54RR026139-01A1/RR/NCRR NIH HHS; 8U54MD007587-0/MD/NIMHD NIH HHS; G12RR-03051/RR/NCRR NIH HHS; P20 RR011126/RR/NCRR NIH HHS; P20-RR011126/RR/NCRR NIH HHS; SA1090922A/SA/BHP HRSA HHS; SC2 AI090922/AI/NIAID NIH HHS; U50-CCU325128-01-01//PHS HHS; U54 CA096300/CA/NCI NIH HHS; U54CA96297/CA/NCI NIH HHS; U54CA96300/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral
Comments/Corrections

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