Document Detail

Is human papillomavirus a causative factor of glottic cancer?
MedLine Citation:
PMID:  21227643     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Human papillomavirus (HPV) infection is controversial as a causative factor of head and neck cancers despite the relatively high frequency of HPV infection in extragenital organ cancers. We aimed to clarify whether HPV directly affects the oncogenesis and biologic behavior of glottis cancer (GC).
METHODS: Paraffin block was obtained from 95 patients who were diagnosed as GC and 15 normal controls. HPV genotyping chip, real-time polymerase chain reaction (PCR) was used for identification of prevalence, phenotype, and physical status of HPV. We compared results with the clinicopathological parameters of GC patients.
RESULTS: HPV was detected in 7.4% (7 of 95) of GC patients, whereas 0% (0 of 15) of controls. Of the HPV-positive tumors in GCs, HPV-16 was the single most common type and HPV-16 prevalence rate was 57.1% (4 of 7). Among the HPV-16 infected GCs, integration of HPV-16 was found only in one case (1 of 4). There was no significant difference in HPV prevalence between GC and controls and HPV had no significant relation with any clinicopathologic parameters of GC patients.
CONCLUSION: HPV infection may not be a causative factor in the oncogenesis and biologic behavior of GC.
Sei Young Lee; Nam Hoon Cho; Eun Chang Choi; Won Shik Kim; Se-Heon Kim
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Publication Detail:
Type:  Journal Article     Date:  2011-01-12
Journal Detail:
Title:  Journal of voice : official journal of the Voice Foundation     Volume:  25     ISSN:  1873-4588     ISO Abbreviation:  J Voice     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  2012-03-15     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  8712262     Medline TA:  J Voice     Country:  United States    
Other Details:
Languages:  eng     Pagination:  770-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 The Voice Foundation. Published by Mosby, Inc. All rights reserved.
Department of Otorhinolaryngology, Chung-Ang University College of Medicine, Seoul, Korea.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / epidemiology,  pathology,  virology*
Case-Control Studies
Glottis / pathology
Human papillomavirus 16 / isolation & purification*
Laryngeal Neoplasms / epidemiology,  pathology,  virology*
Middle Aged
Papillomavirus Infections / complications*,  epidemiology
Republic of Korea / epidemiology
Comment In:
J Voice. 2012 Sep;26(5):676.e21; author reply 676.e23   [PMID:  22578519 ]

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