| Human NK Cells Induce Neutrophil Apoptosis via an NKp46- and Fas-Dependent Mechanism. | |
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MedLine Citation:
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PMID: 22231698 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Polymorphonuclear neutrophils (PMN) are potent inflammatory effector cells essential to host defense, but at the same time they may cause significant tissue damage. Thus, timely induction of neutrophil apoptosis is crucial to avoid tissue damage and induce resolution of inflammation. NK cells have been reported to influence innate and adaptive immune responses by multiple mechanisms including cytotoxicity against other immune cells. In this study, we analyzed the effect of the interaction between NK cells and neutrophils. Coculture experiments revealed that human NK cells could trigger caspase-dependent neutrophil apoptosis in vitro. This event was dependent on cell-cell contact, and experiments using blocking Abs indicated that the effect was mediated by the activating NK cell receptor NKp46 and the Fas pathway. CD56-depleted lymphocytes had minimal effects on neutrophil survival, suggesting that the ability to induce neutrophil apoptosis is specific to NK cells. Our findings provide evidence that NK cells may accelerate neutrophil apoptosis, and that this interaction may be involved in the resolution of acute inflammation. |
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Authors:
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Fredrik B Thorén; Rebecca E Riise; Jenny Ousbäck; Mariella Della Chiesa; Mikael Alsterholm; Emanuela Marcenaro; Silvia Pesce; Carola Prato; Claudia Cantoni; Johan Bylund; Lorenzo Moretta; Alessandro Moretta |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: - ISSN: 1550-6606 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dipartimento di Medicina Sperimentale, Università di Genova, 16132 Genova, Italy; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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