| Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells. | |
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MedLine Citation:
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PMID: 23226797 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP-induced apoptosis. The results suggest that in the absence of hMYH, cells are unable to recognize the damage signal and the ATR pathway is not activated. |
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Authors:
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Soo-Hyun Hahm; Ji Hyung Chung; Lia Agustina; Se-Hee Han; In-Soo Yoon; Jong-Hwa Park; Lin-Woo Kang; Jin Woo Park; Jong Joo Na; Ye Sun Han |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-19 |
Journal Detail:
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Title: Oncology letters Volume: 4 ISSN: 1792-1074 ISO Abbreviation: Oncol Lett Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101531236 Medline TA: Oncol Lett Country: - |
Other Details:
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Languages: ENG Pagination: 1203-1208 Citation Subset: - |
Affiliation:
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Department of Advanced Technology Fusion, Konkuk University, Gwangjin-gu, Seoul 143-701; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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