Document Detail


Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.
MedLine Citation:
PMID:  23226797     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP-induced apoptosis. The results suggest that in the absence of hMYH, cells are unable to recognize the damage signal and the ATR pathway is not activated.
Authors:
Soo-Hyun Hahm; Ji Hyung Chung; Lia Agustina; Se-Hee Han; In-Soo Yoon; Jong-Hwa Park; Lin-Woo Kang; Jin Woo Park; Jong Joo Na; Ye Sun Han
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-19
Journal Detail:
Title:  Oncology letters     Volume:  4     ISSN:  1792-1074     ISO Abbreviation:  Oncol Lett     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101531236     Medline TA:  Oncol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1203-1208     Citation Subset:  -    
Affiliation:
Department of Advanced Technology Fusion, Konkuk University, Gwangjin-gu, Seoul 143-701;
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