Document Detail

Human Milk Oligosaccharides Protect Against Enteropathogenic E.coli (EPEC) Attachment In Vitro and EPEC Colonization in Suckling Mice.
MedLine Citation:
PMID:  24048169     Owner:  NLM     Status:  Publisher    
Breastfeeding reduces the risk of enteric bacterial infections in newborns in part due to human milk oligosaccharides (HMO), complex glycans that are present in human milk, but not in infant formula. Enteropathogenic Escherichia coli (EPEC) are attaching/effacing pathogens that cause serious diarrheal illness with potentially high mortality in infants. We isolated HMO from pooled human milk and found that they significantly reduce EPEC attachment to cultured epithelial cells. In suckling mice, administration of HMO significantly reduced colonization with EPEC compared to untreated controls. These data suggest an essential role for HMO in the prevention of EPEC infections in human infants.
Carolin F Manthey; Chloe A Autran; Lars Eckmann; Lars Bode
Related Documents :
22344849 - Wic infant food package issuance data are a valid measure of infant feeding practices.
21923689 - Establishment of streptococcus mutans in infants induces decrease in the proportion of ...
22105739 - Residential segregation and the health of african-american infants: does the effect var...
22098789 - Reduced maternal mortality in tunisia and voluntary commitment to gender-related concerns.
4041659 - Upper airway reflexes in newborns with respiratory distress syndrome.
21608439 - Prevalence of anaemia in pregnant women during the last trimester: consequense for birt...
2919529 - The prevalence of bacteriuria among high risk neonates in nigeria.
7041039 - Influence on retrolental fibroplasia of intramuscular vitamin e administration during r...
19467009 - Prenatal cocaine exposure and infant cortisol reactivity.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-16
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Department of Medicine †Division of Neonatology and Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093. 1Current address: University Medical Center Hamburg-Eppendorf, Department of Gastroenterology, Martinistrasse 52, Hamburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nutritional Therapy in Pediatric Crohn's Disease: The Specific Carbohydrate Diet.
Next Document:  Outcome Following Infliximab Therapy for Pediatric Patients Hospitalized With Refractory Colitis-Pre...