Document Detail


Human Milk Oligosaccharide Composition Differs between Donor Milk and Mother's Own Milk in the NICU.
MedLine Citation:
PMID:  24282194     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:Human milk oligosaccharides (HMO) represent the third most abundant component of human breast milk. More than a hundred structurally distinct HMO have been identified, and the HMO composition varies between mothers as well as over the course of lactation. Some newborn infants receive donor milk (DM) when their mother's own milk (MOM) volume is inadequate or unavailable.Objective:This study aimed to compare HMO content between DM and MOM.Methods:We used high performance liquid chromatography analysis of fluorescently labeled HMO to analyze the variation in HMO amount and composition of 31 different batches of DM (each pooled from 3 individual donors) provided by the Mothers' Milk Bank in San Jose, California, and compared it to 26 different MOM samples donated by mothers with infants in our neonatal intensive care unit (NICU).Results:Total HMO amount as well as concentrations of lacto-N-tetraose, lacto-N-neotetraose, lacto-N-fucopentaose 1, and disialyllacto-N-tetraose were significantly lower in DM than in MOM, whereas the concentrations of 3'-sialyllactose and 3-fucosyllactose were significantly higher in DM.Conclusion:Our data show that infants in our NICU who receive DM are likely to ingest HMO at different total amounts and relative composition from what they would receive with their MOM. Recent in vitro and animal studies have started to link individual HMO to infant health and disease. Future studies are needed to assess the importance of a mother-infant match with regard to HMO composition.
Authors:
Carolin Marx; Renee Bridge; Alison K Wolf; Wade Rich; Jae H Kim; Lars Bode
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-26
Journal Detail:
Title:  Journal of human lactation : official journal of International Lactation Consultant Association     Volume:  -     ISSN:  1552-5732     ISO Abbreviation:  J Hum Lact     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709498     Medline TA:  J Hum Lact     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Division of Neonatology, Department of Pediatrics, University of California, San Diego, San Diego, CA, USA.
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