| Human Leukocyte Antigen G Expression in Breast Cancer: Role in Immunosuppression. | |
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MedLine Citation:
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PMID: 21510769 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Human leukocyte antigen G (HLA-G) is an immunotolerant nonclassical major histocompatibility complex Class Ib molecule. It is expressed by trophoblastic placental cells during pregnancy to protect the fetus from maternal alloreactivity. HLA-G is overexpressed in tumors and involved in cancer immune evasion. Reverse transcription-polymerase chain reaction and immunohistochemistry (IHC) were used to examine HLA-G expression in normal mammary and breast cancer cell lines and normal and human breast cancer tissues. Reverse transcription-polymerase chain reaction confirmed that normal epithelial MCF-12A cells had no HLA-G mRNA expression, whereas cancer cell lines MCF-7, T47D, and MDA-MB-231 and NCI/Adr-Res had various levels of HLA-G mRNA expression. Twelve (12) normal and 38 breast cancer tissues were examined by IHC. Fifty-eight (58) percent (22/38) of cancers had medium to strong staining to HLA-G, whereas only 8% (1/12) of normal breast tissues had medium to strong staining, and the difference was significant (p < 0.05). HLA-G staining was found in the membranes and cytoplasm of cancer cells. In conclusion, breast cancer cells overexpress HLA-G mRNA and protein, and this probably contributes to immune evasion. |
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Authors:
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Robert L Elliott; Xian P Jiang; Jeffrey T Phillips; Brian G Barnett; Jonathan F Head |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
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Title: Cancer biotherapy & radiopharmaceuticals Volume: - ISSN: 1557-8852 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605408 Medline TA: Cancer Biother Radiopharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Elliott-Elliott-Head Breast Cancer Research and Treatment Center , Baton Rouge, Louisiana. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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