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The Human Leukocyte Antigen DQ2.2 And Celiac Disease.
MedLine Citation:
PMID:  23085892     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: Celiac disease (CD) patients lacking both human leukocyte antigen (HLA)-DQ2.5 in cis (DQA1*05:01, -DQB1*02:01) or trans (DQA1*05:05, -DQB1*02:02) configuration and HLA-DQ8 (DQA1*03:01, -DQB1*03:02) are considered to be rare. Therefore, absence of these genotypes is commonly used to exclude the diagnosis of CD. To investigate whether this approach is justified, the HLA-distribution in 155 children with CD was studied. A total of 139 (89.7%) patients carried HLA-DQ2.5. Of the remaining patients 7 (4.5%) carried HLA-DQ8. Interestingly, the 9 (5.8%) patients lacking HLA-DQ2.5 and HLA-DQ8, carried HLA-DQA1*02:01, -DQB1*02:02 (HLA-DQ2.2). Therefore, HLA-DQ2.2 should be included as an important HLA-type related to CD.
Authors:
Amani Mubarak; Eric Spierings; Victorien Wolters; Ingrid van Hoogstraten; Frank Kneepkens; Roderick Houwen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-18
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Departments of Pediatric Gastroenterology †Immunology, University Medical Center Utrecht, Utrecht, The Netherlands ‡Departments of Pathology §Pediatric Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands.
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