Document Detail

Human intestinal microbiota gene risk factors for antibiotic-associated diarrhea: perspectives for prevention. Risk factors for antibiotic-associated diarrhea.
MedLine Citation:
PMID:  20186408     Owner:  NLM     Status:  MEDLINE    
Antibiotic-associated diarrhea (AAD) is associated with altered intestinal microflora and other symptoms that may lead to possibly death. In critically ill patients, diarrhea increases rates of morbimortality. Assessing diarrhea risks is thus important for clinicians. For this reason, we conducted a hypothesis-generating study focused on AAD to provide insight into methods of prevention. We evaluated the hypothesis of predisposing factors within the resident intestinal microbiota in a cohort of outpatients receiving antibiotherapy. Among the pool of tested variables, only those related to bacterial 16S rRNA genes were found to be relevant. Complex statistical analyses provided further information: amid the bacteria 16S rRNA genes, eight were determined to be essential for diarrhea predisposition and characterized from the most important to the least. Using these markers, AAD risk could be estimated with an error of 2%. This molecular analysis offers new perspectives for clinical applications at the level of prevention.
Marie-France de La Cochetière; Emmanuel Montassier; Jean-Benoit Hardouin; Thomas Carton; Françoise Le Vacon; Tony Durand; Valerie Lalande; Jean Claude Petit; Gilles Potel; Laurent Beaugerie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-26
Journal Detail:
Title:  Microbial ecology     Volume:  59     ISSN:  1432-184X     ISO Abbreviation:  Microb. Ecol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-08-18     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  7500663     Medline TA:  Microb Ecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  830-7     Citation Subset:  IM    
Thérapeutiques Cliniques et Expérimentales des Infections, EA3826, Université de Nantes - INSERM, UFR Médecine, 1 rue Gaston Veil, Nantes, 44000, France.
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MeSH Terms
Analysis of Variance
Anti-Bacterial Agents / adverse effects*
Bacteria / genetics*
Diarrhea / chemically induced,  prevention & control*
Disease Susceptibility / microbiology*
Genes, Bacterial
Intestines / microbiology*
Middle Aged
Multivariate Analysis
RNA, Bacterial / genetics
RNA, Ribosomal, 16S / genetics
Risk Factors
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/RNA, Bacterial; 0/RNA, Ribosomal, 16S

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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