Document Detail


Human intestinal fatty acid binding protein 2 expression is associated with fat intake and polymorphisms.
MedLine Citation:
PMID:  20534879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intestinal fatty acid binding protein (FABP2) is involved in lipid metabolism whereby variations in the promoter (haplotypes A/B) and exon 2 (Ala54Thr) are associated with dyslipidemia and insulin resistance. To elucidate which factors determine FABP2 expression in human mucosa, we investigated the association between fat intake, genotypes, biochemical variables, and FABP2 expression. FABP2 gene expression was assessed in duodenal specimens from 100 participants who answered a FFQ and who were genotyped and characterized for traits of metabolic syndrome and further biochemical data. Homozygotes for haplotype A tended to have lower fat intake than B-allele carriers (P = 0.066). Searching for an explanation, we evaluated the orexigenic glucose-dependent insulinotropic polypeptide (GIP) in a subset from the Metabolic Intervention Cohort Kiel. AA homozygotes had lower postprandial GIP concentrations than BB homozygotes. Duodenal FABP2 expression was correlated with (n-3) fatty acid (FA) intake in AA homozygotes (r = 0.49; P = 0.021). It was higher in AA homozygotes than in B-allele carriers after adjustment for (n-3) FA intake (P = 0.049) and was negatively correlated with serum FFA (r = -0.41; P < 0.01). Our data indicate that FABP2 expression depends on (n-3) FA intake and FABP2 genotypes. FABP2 might be involved in regulating food intake and intestinal FA utilization.
Authors:
Annegret Auinger; Ulf Helwig; Diana Rubin; Julia Herrmann; Gerhard Jahreis; Maria Pfeuffer; Michael de Vrese; Ulrich Robert Foelsch; Stefan Schreiber; Frank Doering; Juergen Schrezenmeir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-09
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1411-7     Citation Subset:  IM    
Affiliation:
Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Department of Physiology and Biochemistry of Nutrition, Kiel, Karlsruhe, Germany. Annegret.Auinger@mri.bund.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Caco-2 Cells
Colon / chemistry
DNA / analysis
Dietary Fats / administration & dosage*
Duodenum / chemistry
Fatty Acid-Binding Proteins / genetics*
Fatty Acids, Omega-3 / administration & dosage
Female
Genotype
Humans
Ileum / chemistry
Intestinal Mucosa / chemistry
Male
Middle Aged
Polymorphism, Genetic / genetics*
Promoter Regions, Genetic / genetics
Reverse Transcriptase Polymerase Chain Reaction
Transfection
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/FABP2 protein, human; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids, Omega-3; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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