Document Detail


Human immunodeficiency virus disease severity, psychiatric symptoms, and functional outcomes in perinatally infected youth.
MedLine Citation:
PMID:  22312169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate associations between human immunodeficiency virus (HIV) disease severity and psychiatric and functional outcomes in youth with perinatal HIV infection.
DESIGN: Cross-sectional analysis of entry data from an observational,prospective 2-year study.Logistic and linear regression models adjusted for potential confounders were used.
SETTING: Twenty-nine sites of the International Maternal Pediatrics Adolescent AIDS Clinical Trials Group study in the United States and Puerto Rico.
PARTICIPANTS: Youth aged 6 to 17 years who had HIV infection (N=319).Main Exposures: Antiretroviral treatment and perinatal HIV infection.
MAIN OUTCOME MEASURES: Youth and primary caregivers were administered an extensive battery of measures that assessed psychiatric symptoms; cognitive, social,and academic functioning; and quality of life.Results: Characteristics of HIV were a current CD4 percentage of 25% or greater (74% of participants), HIV RNA levels of less than 400 copies/mL (59%), and current highly active antiretroviral therapy (81%). Analyses indicated associations of past and current Centers for Disease Control and Prevention class C designation with less severe attention-deficit/hyperactivity disorder inattention symptoms,older age at nadir CD4 percentage and lower CD4 percentage at study entry with more severe conduct disorder symptoms,higher RNA viral load at study entry with more severe depression symptoms, and lower CD4 percentage atstudy entry with less severe symptoms of depression. There was little evidence of an association between specific antiretroviral therapy and severity of psychiatric symptoms.A lower nadir CD4 percentage was associated with lower quality of life, worse Wechsler Intelligence Scale for Children Coding Recall scores, and worse social functioning.
CONCLUSION: Human immunodeficiency virus illness severity markers are associated with the severity of some psychiatric symptoms and, notably, with cognitive, academic,and social functioning, all of which warrant additional study.
Authors:
Sharon Nachman; Miriam Chernoff; Paige Williams; Janice Hodge; Jerry Heston; Kenneth D Gadow
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  166     ISSN:  1538-3628     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-10-16     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-35     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Stony Brook University, Health Sciences Center T-11, Stony Brook, NY 11794, USA. sharon.nachman@stonybrook.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00100542
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antiretroviral Therapy, Highly Active
Child
Cognition*
Cross-Sectional Studies
Depressive Disorder, Major / etiology
Female
HIV*
HIV Infections / complications,  drug therapy,  psychology*
Humans
Male
Mental Disorders / etiology*
Prospective Studies
Puerto Rico
Quality of Life*
Severity of Illness Index
United States
Grant Support
ID/Acronym/Agency:
1 U01 AI068616/AI/NIAID NIH HHS; 5 U01 AI41110/AI/NIAID NIH HHS; U01 AI068632/AI/NIAID NIH HHS; U01 AI068632/AI/NIAID NIH HHS; U01 AI068632-03/AI/NIAID NIH HHS
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