| Human Ile-Ser-bradykinin, identical with rat T-kinin, is a major permeability factor in ovarian carcinoma ascites. | |
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MedLine Citation:
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PMID: 3828072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ascites from patients with metastatic ovarian carcinoma contains high amounts of an activity that increases vascular permeability, as easily detected by a rat skin test. Ascites was fractionated by gel permeation and reversed-phase high-performance liquid chromatographies. The fractions were analysed for permeability-increasing activity. In this way a peptide was isolated and identified as Ile-Ser-bradykinin by sequence and amino-acid analyses. It is identical with T-kinin which has previously been detected as a product of an acute-phase protein, T-kininogen, in rats but never in human material. The so far identified human kininogens, i.e. high- and low-molecular mass kininogens, can only release Met-Lys-bradykinin or its degradations products, as Ile-Ser-bradykinin is not a part of their structure. However, the present results provide evidence that the permeability factor Ile-Ser-bradykinin under certain conditions can be produced in considerable amounts also by human tissues. |
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Authors:
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G Wunderer; I Walter; E Müller; A Henschen |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological chemistry Hoppe-Seyler Volume: 367 ISSN: 0177-3593 ISO Abbreviation: Biol. Chem. Hoppe-Seyler Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-04-30 Completed Date: 1987-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503054 Medline TA: Biol Chem Hoppe Seyler Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1231-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascites / physiopathology* Bradykinin / analogs & derivatives*, physiology Capillary Permeability* Cystadenocarcinoma / physiopathology, secondary Female Humans Ovarian Neoplasms / physiopathology*, secondary Rats |
| Chemical | |
Reg. No./Substance:
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58-82-2/Bradykinin; 86030-63-9/T-kinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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